Award Data

Not Available

DESCRIPTION provided by applicant Sarcopenia defined as age related loss of muscle mass and muscle function and strength is very prevalent among the elderly Sarcopenia is one of the largest public health problems facing a rapidly increasing aging population in the United States and leads to increased incidence of falls fractures and associated morbidities Previous observations from our la ...

DESCRIPTIONprovided by applicantDuchenne muscular dystrophyDMDis an X linked recessive disorder caused by mutations in the DMD gene with a prevalence ofinmale birthsThe consequent loss of functional dystrophin results in the progressive degeneration of skeletal and cardiac muscleDespite significant progress in our understanding of this disease and advances in the development of new therapeutic app ...

? DESCRIPTION (provided by applicant): Manual drug compounding of chemotherapy medications permits deadly dosing errors and toxic drug exposure and therefore poses unnecessary risks to patients and healthcare professionals. Some robotic compounding devices have been developed in response; however, poor drug containment safety capabilities and prohibitive cost and size have limited widespread a ...

Project Summary/Abstract According to the ADA, 25.8 million children and adults have diabetes. Diabetics have an increased risk of complications such as heart disease and are prone to impaired wound healing. A major cause of morbidity and hospitalizationis diabetic foot ulceration (DFUs) that may result in infection, gangrene, amputations requiring prolonged hospitalization, costly treatments, an ...

DESCRIPTION provided by applicant This project aims to improve the accuracy of tests for early tooth decay dental caries specifically for interproximal surfaces where the posterior teeth abut one another In these regions there is no physical space to visually inspect or probe for caries Instead dentists rely on bitewing X rays BWs But dentists cannot tell whether lucencies observed ...

DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

DESCRIPTION provided by applicant Self monitoring has been described as the andquot cornerstone of the behavioral treatment of obesityandquot Consistent self monitoring of energy intake is associated with improved dietary adherence and weight loss and maintenance The problem is that individuals are notoriously bad at self monitoring their intake and suffer from an underreporting bias The s ...

DESCRIPTION provided by applicant Heart attacks i e myocardial infarction or MI occur in more than million patients annually Advances in pharmacological therapy have dramatically improved survival following the initial MI Consequently the number of patients with previous MI continues to increase and as a result put in jeopardy millions of patients for development of heart failure I ...

DESCRIPTION provided by applicant Alzheimerandapos s disease is a neurodegenerative disease of the brain causing impairments to memory and cognitive functions eventually leading to death The causes of Alzheimerandapos s disease and mechanisms of disease progression are not fully understood but an enormous amount of effort is being focused on the issues in research and pharmacologic intervent ...