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DESCRIPTION provided by applicant This project aims to improve the accuracy of tests for early tooth decay dental caries specifically for interproximal surfaces where the posterior teeth abut one another In these regions there is no physical space to visually inspect or probe for caries Instead dentists rely on bitewing X rays BWs But dentists cannot tell whether lucencies observed ...

DESCRIPTION provided by applicant Burkholderia pseudomallei is a Gram negative bacterium that is the causative agent of melioidosis The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding Melioidosis is difficult to trea and diagnose due to the fact that B pseudomallei is resistant to common antibiotics and symptoms are non specific Morta ...

DESCRIPTION provided by applicant The urban container breeding mosquitoes Aedes albopictus and Aedes aegypti are vectors for deadly and debilitating diseases such as dengue and Chikungunya There is no known vaccine or treatment for either disease mosquito control is the only effective means of preventing and managing outbreaks But container species are difficult to manage using conventional ...

DESCRIPTION provided by applicant The Dracula Pipette is a co axial embryo microinjection tool with the injection pipette presented from inside the holding pipette Double nested tips seal against the surface of the spherical embryo when a vacuum is applied in the space between them This allows a portion of the nearside surface of an embryo to be held by vacuum while a glass pipette is passed ...

DESCRIPTION provided by applicant Current radioembolic Y microspheres have been generally recognized as the state of the art for treating primary and metastatic liver tumors However the clinical results vary vastly due to the lack of accurate diagnostic imaging for dose and treatment planning and the lack of image guidance and dose conformation during the administration of Y microsphe ...

DESCRIPTION provided by applicant Abnormal angiogenesis the growth of new blood vessels from existing vasculature plays a central role in more than seventy major health conditions afflicting over one billion people worldwide Uncovering the mechanisms that control angiogenesis promises to fuel the discovery of novel therapies targeting cancer diabetes macular degeneration and others but the ...

DESCRIPTION provided by applicant Specific information about the state of second messengers in drug signaling pathways is key to understanding the mechanism of a drug within the cell The largest class of drug targets is the G Protein Coupled Receptor GPCR and over of all prescription pharmaceuticals target a GPCR These proteins are the focus of many drug discovery programs because they ...

DESCRIPTION provided by applicant The objective of this project is to demonstrate that the Dose Safety Controller DSC improves the health and lives of persons with Type diabetes T D that have become unaware of hypoglycemia This research aims to show that an artificial pancreas AP device using the DSC will safely andamp effectively control blood glucose for T D patients with hypogly ...