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DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

DESCRIPTIONprovided by applicantThe word adolescence derives from the Latin word "adolescere"meaning"to grow up"Adolescence is a crucial period of transition between childhood and legal adulthoodwith individuals following more uncertain and complex paths based on genderraceethnicitysocial classand geographyThe passage to adulthood revolves around a complex web of factorswhich include socialsocioec ...

The past decade has seen major advances in the tools available to neuroscientistsmaking it possible to ask increasingly specific questions regarding which neurons and circuits are correlated withnecessary forand sufficient forspecific behavioral or computational functionsTwo photon laser scanning microscopyTPLSMis a widespread tool that allows three dimensional imaging and photo stimulation deep w ...

Phase II SBIR Validation of a human in vitro system of hepatic steatohepatitis ABSTRACT Non alcoholic steatohepatitis NASH is part of the progressive disease spectrum of non alcoholic fatty liver disease NAFLD a public health crisis affecting of type diabetics and of obese individuals Glucose and insulin regulated de novo lipogenesis in the liver a critical step in the disease ...

Problem Over the last two decades unintentional opioid related overdose has emerged as a major public health threat in the United States This increasingly common yet preventable cause of morbidity and death among users of prescription opioids is partially due to a substantial expansion in the prescription of opioid analgesics to manage acute and chronic pain conditions Within any given year ...

PROJECT SUMMARY ABSTRACT Long emergency department ED wait times resulting from overcrowding occur on a daily basis in to of hospitals and at least once per week in of hospitals It is widely acknowledged that long wait times are correlated to poor health outcomes due to lack of timeliness and inability to administer treatment While there are many causes of prolonged ED wait times ...

Polymer Exploration Group LLC PA Abstract Project Title Antimicrobial catheters with cell and tissue compatibility Abstract Catheter associated urinary tract infections CAUTIs are often encountered with subsequent antibiotic administration contributing to buildup of bacterial resistance Leaving behind customary methods including release of silver and antimicrobials PEG LLC is developin ...

ABSTRACT Obstructive sleep apnea OSA is the most common type of sleep apnea OSA affects an estimated million adults and of all children in the US OSA results in tiredness depression and fatigue and has several associated common comorbidities It is believed that over of OSA remains undiagnosed The prevalence of OSA increases with age and if untreated increases the risk of ...

PROJECT SUMMARY ABSTRACTOne inBlack men will be diagnosed with HIV in his lifetime as compared toinWhite menNearlyof these new HIV cases among African American men are due to heterosexual transmissionDespite thisBlack men who have sex with womenMSWhave received very little empirical attentionThis is a missed public health opportunityFirstBlack men do not routinely use condomsone of the most effect ...

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