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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. SBIR Phase II: Protein A Membrane Columns for Rapid Protein Purification

    SBC: Purilogics, LLC            Topic: 400

    Project Summary This SBIR Phase II project will address the need for capture step chromatography products that dramatically increase the isolation and purification speed for therapeutic biologicsparticularly monoclonal antibody drugsNumerous campaigns are under way to develop new biologics for treating chronic conditionsand there is increasing demand for affordable and fastsmall batch production r ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Ice-free vitrification and nanowarming of large osteochondral grafts for transplantation

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NIAMS

    Resurfacing of articular cartilage with cold stored osteochondral allografts is employed clinically for repair of trauma and osteoarthritis induced articular cartilage surface damageChondrocyte viability of transplanted articular cartilage is accepted as one of the determinants of outcome following osteochondral allograft transplantationWe have previously developed an ice free vitrification method ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Simulation Education for Ebola Healthcare Team Competency

    SBC: SIMTUNES            Topic: NCEZID

    Project Summary This product will keep healthcare workers prepared and safe in the next lethal viral pandemic through innovative simulation education Ebola and other deadly viral diseases represent a major threat to the nation and world At its peak in December Ebola had infected including in the U S and killed people including in the U S By the end of tragically healthcare workers had died Any hos ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Novel therapeutic approach in treatment of glioblastoma using sustained delivery of Connxin43 carboxy-terminal peptide encapsulated in biodegradable nanoparticles in combination with temozolomide

    SBC: FirstString Research, Inc            Topic: 102

    PROJECT SUMMARY GlioblastomaGBMis an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomideTMZEfforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brainIn contrastsensitizing GBM to TMZ is an appealing strategy because TMZ has excelle ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Administrative Supplement to Promote Diversity in Research and Development Small Businesses

    SBC: Neuroene Therapeutics, LLC            Topic: NINDS

    Abstract Neuroene Therapeutics is a biotech company established to develop and commercialize safe effective therapies for epilepsyinpeople develop epilepsy in their lifetimehowever the currently available anti epileptic drugsAEDshave several issues and liabilities that leave unmet market needssuch asnot controlling seizures forof patients with epilepsycurrent AEDs only treat the symptoms of epilep ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. An HXYZ-g HR-Fast-MAS probe for Dramatically Improved Biomolecular Structure Determinations

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    An HXYZ g HR Fast MAS probe for Dramatically Improved Biomolecular Structure Determinations AbstractLiquid state NMR spectroscopy is arguably one of the best tools for structure determination for soluble proteinsThe method provides atomic resolution for modest molecular weight proteins and or their complexesThe method begins to have difficulty when the molecular weight of the system causes slow mo ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Stroke Treatment by Chemically-induced Hypothermia

    SBC: JT Pharmaceuticals, Inc.            Topic: 100

    ABSTRACTWhile acute stroke is a leading cause of human death and disability in the United Statesunfortunatelyclinical therapies for stroke are limited and unsatisfactoryThe overwhelming failures of stroke treatments in clinical trials strongly indicate thatto battle this multifaceted brain disordernovel strategies that target multiple cell types and afford different mechanisms of protection are ne ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Establishing the Functional Viability and Dose Response of Duck Duck Punch A Stroke Rehabilitation Computer Game

    SBC: Recovr, Inc.            Topic: 108

    Establishing the functional viability and dose response of Duck Duck Punch A Stroke Rehabilitation Computer Game ABSTRACT Only of stroke survivors experience full recovery of arm hand movement Long term arm movement impairment restricts independence with self care and vocational activities increases caregiver burden and reduces quality of life Strong evidence is emerging that traditional ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Closed Loop MAS DNP NMR at K for Affordable Dramatic Gains in S N

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    DESCRIPTION provided by applicant NMR is arguably the most powerful analytical technique for structure determination and function elucidation in molecules of all types but there are complex challenges for biological macromolecules Dynamic Nuclear Polarization DNP with Magic Angle Spinning MAS has recently demonstrated S N gains of up to two orders of magnitude at K the lower tempera ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health

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