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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Adaptive Clinical Efficacy Evaluation of ONC201 in Recurrent High Grade Glioma

    SBC: Oncoceutics, Inc.            Topic: 102

    Project Summary We propose a two-arm adaptive Phase II clinical trial to evaluate ONC201, a selective antagonist of the G protein-coupled receptor (GPCR) dopamine receptor domain 2 (DRD2), in recurrent glioblastoma (GBM) and diffuse midline glioma associated with very poor prognoses and limited treatment options. DRD2 is overexpressed in high grade gliomas and controls Akt/ERK signaling pathways. ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 368: Biotherapy of Brain Tumors by Radioiodinated SapC-DOPS Nanovesicles

    SBC: MOLECULAR TARGETING TECHNOLOGIES, INC.            Topic: NCI

    There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. History Maker

    SBC: Schell Games LLC            Topic: 91990018R0006

    In this project, the team will develop a prototype of History Maker, a virtual reality (VR) content creation tool, where students and teachers produce digital movies to be used as reports and/or presentations about particular historical topics. Within the platform, students will research primary sources documents, write scripts, and act scenes from history. Student work will be presented in VR to ...

    SBIR Phase I 2018 Department of EducationInstitute of Education Sciences
  4. Plasma-Enhancement of Absorbers for Improved Removal of PFOS and PFOA from Water

    SBC: AA PLASMA LLC            Topic: 17NCER1A

    New regulations and advisory levels for perfluoroalkyl substances have resulted in increased drinking water treatment costs or abandonment of drinking water sources. Treatment technologies are needed that can achieve low parts-per-trillion levels. Presently, there are insufficient treatment technologies that can destructively remove perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonic aci ...

    SBIR Phase I 2018 Environmental Protection Agency
  5. Topic 373: Monoclonal Antibodies to RNA-modifications

    SBC: ABZYME THERAPEUTICS LLC            Topic: NCI

    Post-transcriptional RNA modification is quite complex as there are more than sixty known RNA modifications that occur in thousands of RNAs in eukaryotic cells. A number of these RNA modifications have been shown to influence the development and physiology of the central nervous system (CNS) and to be involved in carcinogenesis. Despite the growing interest in and importance of RNA modifications, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Topic 373: Novel Mass Spectrometry Methods and Research Tools to Map Nucleotide Modifications in Cytosolic Transfer RNAs from Cancer Cells

    SBC: Ribonova Inc.            Topic: NCI

    Chemical modifications play a crucial role in the regulation of biological processes. Protein function is often modulated by tagging with phosphates, sugars, or lipids, while epigenomic marks on DNA or histones can regulate gene expression up or down. One area that lags behind is the mechanistic understanding of the role of RNA chemical modifications, sometimes referred to as the 'epitranscriptome ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Piezoelectric Ring Mounted Oscillated Syringe System for Lower Distress, Lower Force, Laboratory Animal Vascular Access and Injection to Improve Data Quality and Laboratory Animal Welfare

    SBC: ACTUATED MEDICAL, INC.            Topic: 200

    This Fast track SBIR developstestsand commercializes aPiezoelectric Ring Mounted Oscillated Syringe System for Lower DistressLower ForceLaboratory Animal Vascular Access and Injection to Improve Data Quality and Laboratory Animal WelfareThe Oscillated Needle InserterONIis a simple one handedvascular access device that uses a novel vibratory piezoelectric ring to directly apply longitudinal microos ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. An Acoustofluidic Device for Biocompatible Platelet Separation

    SBC: Ascent Bio-Nano Technologies Inc            Topic: NHLBI

    Project Summary The ability to perform platelet separation with a high throughputhigh recovery ratehigh purityand high platelet integrity is extremely important in many biomedical research studies and therapeutic applicationssuch as platelet transfusionsCentrifugation is currently thegold standardlaboratory technique used to obtain platelets from whole bloodHoweverthis current approach for platele ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. A Computer Tool for Aiding in Accurate Assessment of Indeterminate Lung Nodules

    SBC: International Intelligent Informatics Solution Laboratory LLC            Topic: 101

    Low dose CT screeningLDCThas been approved by the Centers for Medicare andampMedicaid ServicesCMSfor Medicare coverageHoweverthe primary problem associated with CT is the high false positivedetectionsThis issue often leads to unpleasant and costly unintended consequencese gfollow up scans and or invasive biopsiesIn this projectwe propose to develop and commercializea novel computer tool to aid in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of an acoustofluidic-based C.elegans 3D imaging and sorting system

    SBC: Ascent Bio-Nano Technologies Inc            Topic: OD

    Project Summary Drug development has become an extremely expensive and time consuming processIt is for this reason that many efforts are being made to overhaul how potential drugs are brought to marketBy lowering the cost in the developmental and testing phasesthe inflated end costs can be controlledThe use of model organisms as a cheaper explorative method prior to human testing hasand must conti ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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