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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Randomized Prospective Phase II Clinical Trial of NVX in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme GBM is a malignant primary brain tumor affecting about new cases per year in the U S Average survival is only about months Radiation RT is most commonly administered as fractions of Gray each over weeks with concomitant temozolomide TMZ GBM tumors are hypoxic The primary mechanism of RT is creation of singlet oxygen hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Disaggregation of Toxic Protein Oligomers in Brain with Electromagnetic Treatment

    SBC: NeuroEM Therapeutics, Inc.            Topic: 104

    ABSTRACT Formation of misfolded protein oligomers in neurons is an early and causative event in a variety of neurodegenerative diseases such as Alzheimer s Disease amyloid and tau oligomers Fronto temporal lobe dementia tau oligomers and Parkinson s Disease synuclein oligomers These toxic oligomers share a common aggregation mechanism that involves formation of hydrogen bonds betwee ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Application of PPODA QT for embolization of aneurysms

    SBC: Aneuvas Technologies, Inc.            Topic: 101

    A cerebral aneurysm is an abnormal enlargement or pouch that forms from a weakened vessel segment in the brain Often going unnoticed and untreated an aneurysm can cause a sudden and catastrophic hemorrhage or stroke Approximately of patients die from an aneurysm rupture even before receiving medical attention and of patients die despite medical treatment Patients that survive typical ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Polo box PLK Inhibitors Target Tumors Resistant to ATP Competitive Compounds

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    Polo like kinase PLK is a central player in regulating entry into and progression through mitosis Many studies have validated PLK as an anti tumor drug target and its inhibition is potently anti proliferative to cancer cells However recent data suggests that there are two major disadvantages of the conventional approach to blocking the kinase activity of PLK First both general kinome ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Regulators of NaV Channels Novel Anti Allodynic Drug Candidates

    SBC: Regulonix            Topic: 102

    PROJECT SUMMARY Chemotherapy induced peripheral neuropathy CIPN is a common prevalence and potentially dose limiting side effect of many cancer chemotherapy drug treatment regimens Clinically CIPN presents with pain that is burning shooting or electric shock like The increase in prevalence of cancer coupled with an increase in the cancer survival rates due to chemotherapy regimens ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Dodecafluoropentane Prevents Ischemia Reperfusion Injury in Contemporary Acute Myocardial Infarction Management

    SBC: NUVOX PHARMA, L.L.C.            Topic: NHLBI

    Due to multiple factors time to administration of lytic therapy or emergent percutaneous coronary intervention PCI in acute ST segment elevation myocardial infarction STEMI may be delayed resulting in loss of additional myocardial tissue These delays are virtually impossible to overcome in remote regions and are associated with increased mor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of the Building Efficacy for Successful Tapering BEST Program

    SBC: GOALISTICS, LLC            Topic: NIDA

    ABSTRACT Over million Americans suffer from chronic pain The use of chronic opioid therapy COT for pain has increased dramatically as have reports of opioid misuse abuse dangerous interactions with other drugs overdose and death As concerns over the alarming effects of COT have risen regulatory efforts have increased as well including medically supervised opioid tapering Tapering ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. HazPrep Worker Training Community Risk Profile

    SBC: Inxsol LLC            Topic: 142

    PROJECT SUMMARY ABSTRACT A workerandapos s personal hazard profile PHP is a function of hazards present and his her exposure level to those hazards Workers with an elevated level of risk are those who can be engaged in activities related to or working around hazardous materials waste generation removal containment transportation and emergency response inXsol believes two components a ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A Novel Scaffold to Promote Skin Regeneration

    SBC: FirstString Research, Inc            Topic: NIAMS

    PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A Novel Millimeter wave mmw DNP EPR Front end Compatible with Versatile High field NMR Probes

    SBC: DOTY SCIENTIFIC, INC.            Topic: NIA

    A Novel Millimeter wave mmw DNP EPR Front end Compatible with Versatile High field NMR Probes Abstract There has been explosive growth in interest in Dynamic Nuclear Polarization DNP with Magic Angle Spinning MAS over the past five years because it has demonstrated S N gains exceeding two orders of magnitude at K compared to conventional MAS NMR and non spinning NMR of biological macro ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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