Award Data

Project Summary Abstract Motor vehicle crashes are the leading cause of unintentional morbidity and mortality among children in the United States and a leading cause of brain injuryBrain injuries resulting from the child s head impacting surfaces in the vehicle during a frontal crash are a significant problem and head injury is the leading cause of death and serious injury for children in crashesC ...

The goal of this fast track STTR proposal is to expand buprenorphine maintenance therapy for opioiddependent patientsOvermillion people in the US are addicted to opiatesProviding effective agonist therapymethadone or buprenorphinecoupled with behavioral counseling greatly improves outcomesreduces morbidityand reduces societal costsMethadone maintenance treatment has been limited due to complex sta ...

Project Summary Abstract Proposed is an easy to useportable method for diagnosis of obstructive sleep apneaOSAusing non contact technology for use in clinical or home settingSignificanceAn estimatedmillion Americans have sleep apnea and recent epidemiological studies indicate the prevalence of this disorder is on the riseOSA is associated with several negative health outcomes including depression ...

Approximatelymillion Americans suffer from asthmawhich leads to aboutdeaths per yearand is responsible for estimated annual total direct and indirect costs of $billionDespite the existing treatments for asthmapredominantly combinations of inhaledagonists and corticosteroidsCSsthere remains a significant unmet medical need for new therapies which address two key issuesapproximatelyof patients are i ...

Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

Abstract Fourteen percent of thoseand older in U Ssuffer from dementia and overmillion older Americans are living with Alzheimerandapos sByovermillion will have this disease and will experience impairments in cognitive and intellectual abilitymemorylanguagereasoningand judgment that interfere with everyday functioningCaregivers committed to person centered dementia care seek non pharmacological th ...

Project Summary Abstract Combining high channel count electrophysiological recording of neural activity with patterned electrical microstimulation has been severely constrained by technical limitationsForemost among these limitations are the problems associated with simultaneous recording and micro stimulationStimulation artifacts are up to four orders of magnitude larger than the neural signal be ...

ABSTRACTThetis plans to investigate TPan innovative and potential first in class therapeutic agentas an oral therapy for the induction and maintenance of remission of intestinal inflammation symptoms in ulcerative colitisUCpatientsWhile the precise etiology of UC is unknownit is thought to result from an inappropriate inflammatory response to commensal gut bacteria in genetically susceptible indiv ...

Abstract Koronis Biomedical Technologies and its collaborators propose to develop and fully test a low costportable respiratory assessment device using the forced oscillation techniqueFOTleveraging the development of a new flexible thin film airflow sensor technologyThe proposed FOT device requires zero skill for the subject and operator making it ideal for occupational health screeningphysician o ...

ABSTRACT When Cryptococcus is manifested as cryptococcal meningitis (CM), it creates a large burden of mortality and morbidity to the patient and is very difficult for the clinician to treat. There are now an estimated 2600-7800 US cases and 400,000 cases of CM worldwide annually, with estimated mortality of 15-50% per year. CM is caused when Cryptococcus neoformans, a basidiomycete fungal pathoge ...