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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. SBIR TOPIC 096: Novel Biodegradable Metal Stents for Neonatal Aortic Coarctation

    SBC: Pediastent LLC            Topic: NHLBI

    Most stents used to repair congenital heart lesions only need to serve as temporary scaffoldingsBecause pediatric patients have growing cardiovascular structuresthere is great interest in use of bioresorbable stentsBRSfor the treatment of coarctation of the aorta in neonatesA pediatric bioresorbable stent would allow thousands of infants each year to avoid the morbidity and mortality of more invas ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Cancer Imaging and Therapy Analysis Platform (CITAP)

    SBC: BIOINVISION INC.            Topic: 102

    Cancer Imaging and Therapy Analysis PlatformCITAPSummary We will create a preclinicalquantitativeCancer Imaging and Therapy Analysis PlatformCITAPpronounced sea tapwhich will allow one to study cancer biology and optimize pipelines of technologiesimaging agentsimaging methodstargeted nano therapeuticsimmunotherapytumor modelsetcespecially for metastatic and invasive cancersTodayprimary tumor masse ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Novel therapeutic approach in treatment of glioblastoma using sustained delivery of Connxin43 carboxy-terminal peptide encapsulated in biodegradable nanoparticles in combination with temozolomide

    SBC: FirstString Research, Inc            Topic: 102

    PROJECT SUMMARY Glioblastoma (GBM) is an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomide (TMZ). Efforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brain. In contrast, sensitizing GBM to TMZ is an appealing strategy because TM ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Early Feasibility Clinical Study of the VitalFlow Stimulator, an Emergency Treatment for Ischemic Stroke

    SBC: NERVIVE, INC.            Topic: 106

    PROJECT SUMMARY Stroke is the world’s greatest healthcare burden for which few treatment options are available. The long-term objective of the applicant, Nervive, Inc., is to bring to market a non-invasive medical device, the VitalFlow stimulator, as an emergency treatment for ischemic stroke. The VitalFlow is a novel technology that activates the autonomic components of the facial nerve using p ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Administrative Supplement to Promote Diversity in Research and Development Small Businesses

    SBC: Neuroene Therapeutics, LLC            Topic: NINDS

    Abstract Neuroene Therapeutics is a biotech company established to develop and commercialize safe effective therapies for epilepsyinpeople develop epilepsy in their lifetimehowever the currently available anti epileptic drugsAEDshave several issues and liabilities that leave unmet market needssuch asnot controlling seizures forof patients with epilepsycurrent AEDs only treat the symptoms of epilep ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel, Non-Cytotoxic, Epigenetic Therapeutic for Sickle Cell Disease

    SBC: DeNovoTherapies LLC            Topic: NHLBI

    TBD

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Testing and Commercialization of a Superior Device to Maintain Perioperative Normothermia In Anesthetized Patients

    SBC: Mercury Biomed LLC            Topic: 300

    Project SummaryAbstractThis proposal presents Phase II of Mercury Biomedandapos s plan for commercializing the new and innovative WarmSmart technology to more effectively keep surgical patients normothermicWarmSmart embodies several breakthrough concepts in bioheat transfer to manage core temperatureWe are building a costcompetitive patient warming technology that will be superior to existing tech ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Non-Invasive Intraoral LED Phototherapy Device for the Prevention and Treatment of Oral Mucositis

    SBC: Lumitex, Inc.            Topic: NIDCR

    PROJECT SUMMARY ABSTRACT The goal of this SBIR is to create a novel phototherapeutic light delivery device which will advance the standard of care for the prevention and treatment of Oral MucositisOMOM is one of the most common and highly significant toxicities of cancer therapyApproximatelypatients are affected by OM in the United States each yearOM is an extremely painful condition which breaks ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Rapid response toxicology prediction platform

    SBC: LEADSCOPE, INC.            Topic: NIEHS

    Project Summary Abstract In silico toxicology is an important alternative approach to animal testing that provides a fast and inexpensive prediction of toxicityIt uses computer models to predict whether a chemical is safe or if there is a potential hazardIn silico methods are particularly valuable when a decision needs to be made quicklysuch as for an emergency response to a chemical spill or when ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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