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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. HLS Potent, novel inhibitor of fibrinolytic hemorrhage- Phase II

    SBC: Translational Sciences Inc.            Topic: NHLBI

    This SBIR Application is responsive to NHLBI Small Business Topics of Special Interest (therapeutics) that are of high programmatic interest (HLS-17-04). Hemorrhage or bleeding is a serious or fatal complication of surgery. Antifibrinolytic agents that inhibit plasmin-mediated fibrinolysis can significantly reduce blood loss, emergency reoperation, morbidity and death in patients with severe hemor ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Targeting DNA damage response pathways for the treatment of advanced lung cancer

    SBC: CUMBERLAND PHARMACEUTICALS INC.            Topic: 102

    ABSTRACTThere is an urgentunmet need for novel therapeutic approaches that are efficacious against lung cancerRanking first among cancer deaths in the U Sthis disease hasyear relative survival rates of andltMost lung cancers are non small cellNSCLCof casesCurative surgery is not an option for theof NSCLC patients who present with advanced stage III cancerFor these patients chemo radiation therapy ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Novel therapeutic approach in treatment of glioblastoma using sustained delivery of Connxin43 carboxy-terminal peptide encapsulated in biodegradable nanoparticles in combination with temozolomide

    SBC: FirstString Research, Inc            Topic: 102

    PROJECT SUMMARY Glioblastoma (GBM) is an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomide (TMZ). Efforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brain. In contrast, sensitizing GBM to TMZ is an appealing strategy because TM ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Administrative Supplement to Promote Diversity in Research and Development Small Businesses

    SBC: Neuroene Therapeutics, LLC            Topic: NINDS

    Abstract Neuroene Therapeutics is a biotech company established to develop and commercialize safe effective therapies for epilepsyinpeople develop epilepsy in their lifetimehowever the currently available anti epileptic drugsAEDshave several issues and liabilities that leave unmet market needssuch asnot controlling seizures forof patients with epilepsycurrent AEDs only treat the symptoms of epilep ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Long non-coding RNA signatures to distinguish fibromyalgia syndrome from rheumatic diseases

    SBC: IQuity Labs, Inc.            Topic: R

    No other group of diseases encompasses a greater pathophysiology than do the rheumatic diseasesSpanning multiple organ systemsclinical decisions often rely on coordinated efforts from primary care providers and rheumatologists to rule in or rule out differential diagnoses when treating inflammatory conditions such as rheumatoid arthritisRAand systemic lupus erythematosusSLERA is a symmetricinflamm ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Enhancing Administrator Coaching of Classroom Teachers

    SBC: Liveschool Inc.            Topic: 99190018R0005

    Purpose: In previous research and development, the team created LiveSchool, a technology for teachers to report student behavior in their class. In this project, the team will fully develop and test ClassCoach, a dashboard for administrators to track student behavior and to recommend resources teachers can use to address student behavioral needs in their classes. Over the past several years, schoo ...

    SBIR Phase II 2018 Department of EducationInstitute of Education Sciences
  7. Point of care assay for serodiagnosis of Leptospirosis

    SBC: Immuno Technologies, Inc.            Topic: NIAID

    Leptospirosis is the most widespread neglected zoonotic disease in the worldIt affects vulnerable populations such as rural subsistence farmers and urban slum dwellersUrban epidemics are reported in cities in developing countries and will likely increase as the world s slum population doubles tobillion byAn unexpected outbreak was reported in New York City recently and climate change may account f ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. A Molecular Diagnostic Assay for Accurately Differentiating Melanoma from Benign Lesions

    SBC: Frontier Diagnostics, LLC            Topic: 102

    AbstractMelanoma is the third most common form of skin cancer with estimatednew cases diagnosed in the United States in the yearCurrent routine diagnostic approaches utilize microscopic evaluation of thinly sectioned patient biopsiesbut in certain cases diagnosis can be contentious even among expertsThe overall goal of this multi phase SBIR project is to developvalidateand commercialize MelanoMapT ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. DMSO-free Cryopreservation of Bone Marrow-derived Stem Cells

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NHLBI

    ABSTRACT Stem cell transplantation in the form of bone marrowperipheral blood or cord blood derived cells is commonly performed for reconstitution of the hematopoietic system of patients suffering from cancers and non malignant diseasesCurrent practice for cryopreservation of hematopoietic and mesenchymal stem cells is to employ the cell permeating cryoprotectant dimethylsulfoxideoften with an add ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Construction and testing of a rabbit cornea-equivalent for evaluation of chemical injury in vitro

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NIEHS

    ABSTRACTWe propose combination of the rabbit cornea endothelial and epithelial cells with bioengineered scaffolds in cell culture well insertsThis technology could significantly reduce the use of rabbits for the Draize rabbit eye irritation assayThe barrier to commercialization is the lack of an effective method for storingbankingof living bioengineered cornea equivalentsWe will combine cell expan ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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