Award Data

This STTR project's broader/commercial impact is that it will allow researchers to learn more about the complex relationships between environmental conditions and the impact of changes over time. The ability to convey that knowledge in an intuitive and compelling manner to students and the public globally could motivate them to influence business and political leaders to craft policies that w ...

This Small Business Innovation Research (SBIR) Phase II project represents a new development in man?s ability to keep birds away from the airspace surrounding an airplane or out of the way of the massive rotors of wind turbines. Animals respond to a bright ultraviolet light in the same way as humans respond to a bright flashlight in their eyes. If the light is strong enough, it causes an involunta ...

This Small Business Innovation Research Phase II project will optimize large-scale production of latex polymers from alkyl itaconates. These latexes represent a new class of polymers that offer desirable properties in wood, textile, paper and adhesive coatings, including low odor, no VOC contribution, and bio-based production. Itaconix has previously developed cost-effective emulsion polymerizatio ...

DESCRIPTION (provided by applicant): The goal of this project is to develop a plasmid-based therapy that will destroy the integrated HIV-1 DNA (HIV- 1 provirus) in infected cells. Current HIV-1 anti-retroviral therapy (ARV) consists of a cocktail of drugsthat blocks viral binding and replication, but does not destroy the HIV-1 provirus. In addition, ARV does not impact the large reservoir of laten ...

DESCRIPTION (provided by applicant): There is currently no effective treatment for recurrent small-cell lung cancer (rSCLC). The objective of this project is to utilize a monoclonal antibody, MAG-1, to develop new, rational, and successful treatment of rSCLC. The hypothesis being tested is that a cancer -specific provasopressin antigen, called GRSA, present at the surface of these tumors will prov ...

DESCRIPTION (provided by applicant): The long-term aim of this project is to reduce or eliminate the serious adverse events associated with cellular immunotherapy used to treat cancer. The current impressive efficacy of chimeric antigen receptor (CAR) T cell therapies is often accompanied by a well-known toxicity stemming from the large release of cytokines from activated immune cells, known as a ...

DESCRIPTION (provided by applicant): This proposal responds to the NIDCD special solicitation RFA-DC-12-004 for improving access to hearing healthcare. In particular, the NIDCD is seeking solutions to lower the cost of hearing healthcare and improve accessfor underserved populations (such as the disabled and communities with limited resource access). Technologies that achieve the initiative object ...

DESCRIPTION (provided by applicant): The diabetes epidemic, and the devastating complications that accompany it, have created an unprecedented worldwide medical crisis. It is primarily the complications of diabetes, including kidney failure, blindness, cardiovascular disease and neuropathy that accounts for the 245 billion spent in 2012 in the US. A significant problem for doctors who treat diabe ...

DESCRIPTION (provided by applicant): Ischemia-reperfusion (I/R) injury during renal transplantation surgery is responsible for oxidative stresses which result in immune activation and graft rejection. We are developing an antioxidative therapy that we havealready shown to be highly efficacious in ameliorating damage from oxidative stress in various in vitro models as well as I/R models of kidney, ...

DESCRIPTION (provided by applicant): Over the last three decades the number of men diagnosed with prostate cancer has increased 85% as a result of new screening and diagnostic tools. However, a significant number of these newly diagnosed men are harboringclinically insignificant disease, which means that they are not likely to die from prostate cancer. A difficul decision facing urologists daily i ...