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This proposal was submitted under the Small Business Innovative Research (SBIR) Fast-track process. In Phase I, that concluded in September, 2014, the primary purpose was to develop a sensor-enhanced health information system for many different health contexts including prevention and management of chronic diseases such as cancers. In Phase II, Vignet will combine several innovative technologies a ...

MATSYS proposes to develop reactive materials compositions and processing techniques for structural reactive composites for blast enhancement. This effort will combine our unique expertise in instrumented-Hot Isostatic Pressing (HIP) with new approaches in reactive materials design to develop a new generation of cost-efficient and highly reactive materials. The proposed material system will use a ...

DESCRIPTION provided by applicant Advances in DNA sequencing technology have now made it practical and affordable to generate datasets containing millions of genetic attributes that can be tested for association with disease susceptibility The computational complexity of searching for genetic interactions over such high dimensional datasets imposes great challenges for genome wide associatio ...

DESCRIPTION provided by applicant All forms of diabetes are characterized by the death of insulin producing cells In Type diabetes T D this leads to the reliance on exogenous insulin for survival Death of cells is silent it cannot be detected in vivo until it has progressed to such an extent that metabolic function is impaired The loss of cells has only been assessed by functiona ...

DESCRIPTION provided by applicant Lyme disease LD caused by the Ixodes tick borne spirochete Borrelia burgdorferi Bb is the most common vector borne disease in the United States Despite public health preventive measures the annual confirmed case incidence has risen to over the vast majority of which occur in the Northeast Disseminated infection causes disease in the skin heart ...

DESCRIPTION provided by applicant This Phase II project will develop a novel synthetic microparticle vaccine for malaria using the T BT epitopes of the circumsporozoite CS protein of Plasmodium falciparum the causative agent of human malaria There is no approved vaccine for malaria a disease that causes up to million new infections and million deaths each year in the developing wor ...

DESCRIPTION provided by applicant Current testing for Lyme disease is suboptimal because it requires two assay platforms including one with subjective interpretation of results and because it has lower sensitivity in the early stage of the illness Infection with Borrelia burgdorferi the causative agent of Lyme disease is transmitted by the bite of an Ixodid tick and results in uniformly lo ...

DESCRIPTION provided by applicant The Virtual Occupational Therapy Assistant VOTA will enable stroke patients to practice activities of daily living ADLs as part of an in patient skilled nursing outpatient home health and or teletherapy rehabilitation program The system leverages low cost human motion tracking advanced kinematic pose estimation algorithms and state of the art game e ...

DESCRIPTION provided by applicant Lung cancer is the leading cause of cancer death in the United States and is responsible for more deaths each year than breast prostate colon hepatic renal and skin cancers combined Viewed in economic terms in the United States the value of life lost from lung cancer deaths in the year was more than $ billion which is estimated to rise to more t ...