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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A2A receptor blockade for sepsis

    SBC: Purine Pharmaceuticals Inc.            Topic: NIAID

    SUMMARY Sepsis is a clinical syndrome that complicates severe infectionSepsis remains the leading cause of morbidity and mortality in critically ill patientsThere are no specific FDA approved medicines for the treatment of sepsisCurrent concepts of the pathophysiology of sepsis suggest that organ failure and mortality in sepsis are caused by inappropriate regulation of the immune systemThis manife ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A biochemical companion diagnostic platform to measure kinase inhibitor pharmacodynamics in leukemia

    SBC: MICROFLUIDIC INNOVATIONS, LLC            Topic: 102

    DESCRIPTION provided by applicant Kinase inhibitors created a new paradigm in chemotherapy and are a major focus of new oncology drug development The Bcr Abl inhibitor imatinib was a breakthrough drug for chronic myelogenous leukemia with overwhelming early results however at least of patients are either intolerant resistant or experience recurrence within years and individual respo ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. ABL (Airborne Laser) Detection Sensor Improvements

    SBC: Aerodyne Research, Inc.            Topic: MDA06T006

    The first sentinel of ABL’s present target acquisition suite is a passive infrared search and track sensor of 1970s vintage, which we propose replacing with HyPAWS. HyPAWS is a low-cost passive wide-field of view staring sensor. Several such units suffice to provide full 360-degree view coverage. Leveraging revolutionary sensing techniques in ongoing development, HyPAWS offers advanced detect ...

    STTR Phase I 2006 Department of DefenseMissile Defense Agency
  4. Access to Exercise Stress Testing for Elderly Native Americans in Remote Locations

    SBC: ADVANCED MEDICAL ELECTRONICS CORPORATION            Topic: N

    DESCRIPTION provided by applicant Heart disease is the leading cause of death among elderly American Indians and Alaska Natives Heart disease death rates for elderly American Indians at per are percent higher than average in the total U S population Most elderly Native Americans live in remote locations and lack transportation to healthcare facilities This is a key barrie ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. A Cloud based Application for the Joint Analysis of Multiple Big Data Types

    SBC: MathNimbus Inc            Topic: 400

    Project Summary Technology advances now enable the cost effective acquisition of Kandgt distinct data types from a common set of N bio samples where i the kth data type is represented by a data matrix with columns containing Pk measurements in N samples for k K and ii at least one of the data types is big i e Pk is much bigger than N for some k The rapid accumulation of such mult ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A cloud based software platform to enhance reproducibility collaboration and translation of stem cell research

    SBC: Cellara, LLC            Topic: 400

    Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  8. Adaptive, Efficient, and Agile Guidance for Ascent Phase Intercept

    SBC: Sysense Incorporated            Topic: MDA08T003

    The proposed effort will further refine the adaptive model-based estimation and control guidance law developed during the Phase 1 effort to work in a two-tier algorithm with an agile, game-theoretic guidance law that is immune to the acceleration of the target. The two-tier approach is used to bring the intercept vehicle close to the target while conserving fuel but still obtains good minimal mis ...

    STTR Phase II 2012 Department of DefenseMissile Defense Agency
  9. Adaptively Cooled Wavefront Error Correction for Enhanced Hypersonic KV IR Seeker Windows

    SBC: MILSYS TECHNOLOGIES, LLC            Topic: MDA04T002

    Strategic missile defense will directly benefit from increasing the operational infrared bandwidth from just a 3mm-5.5mm capability to a 1mm - 12mm capability. Increased seeker spectral bandwidth will enable improvements in detection range, acquisition performance, discrimination of unresolved objects, and aimpoint selection in the presence of a target plume. The mission outlined requiring an op ...

    STTR Phase I 2004 Department of DefenseMissile Defense Agency
  10. Adaptive Management and Mitigation of Uncertainty in Fusion (AMMUF)

    SBC: Charles River Analytics, Inc.            Topic: MDA13T001

    Missile defense takes place in an uncertain and dynamic environment, so multi-sensor fusion must be employed to aggregate and merge disparate data from the battlefield. However, the fusion process is hindered by the vast amount of uncertainty in operational contexts, such as imprecise measurements and varying environmental conditions. Various algorithms and fusion processes have been developed to ...

    STTR Phase I 2014 Department of DefenseMissile Defense Agency
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