Award Data

We will develop and test a simulator of diagnostic vascular ultrasound for use in medical education and professional certification. The simulator will include not only two-dimensional (2D) images but also Doppler spectral waveforms to simulate duplex ultrasound scanning. The rationale is that education in diagnostic ultrasound has traditionally been based on an extended duration of clinical exposu ...

DESCRIPTION provided by applicant Burkholderia pseudomallei is a Gram negative bacterium that is the causative agent of melioidosis The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding Melioidosis is difficult to trea and diagnose due to the fact that B pseudomallei is resistant to common antibiotics and symptoms are non specific Morta ...

DESCRIPTION provided by applicant Amyotrophic lateral sclerosis ALS or Lou Gehrigandapos s disease is a fatal neurodegenerative disease with a typical lifespan of years after diagnosis The initial symptoms can be similar to many other neurologic disorders and often begin with limb weakness muscle fasciculations or increasing difficulties in speech or breathing No definitive diagnost ...

This proposal examines innovative approaches and technologies that can be used to evaluate legacy models and simulations, determine the feasibility of porting them to multi-core simulation environments, and enable the legacy model capabilities to efficiently execute in such multi-core environments. We will employ Discrete Event System Specification (DEVS) Simulator architectures to support highly ...

DESCRIPTION (provided by applicant): Congenital heart disease (CHD) ranges from benign lesions to life-threatening structural abnormalities. While benign lesions may resolve without intervention, severe structural lesions require complex pediatric cardiacsurgery. The reconstruction of the aortic arch in children is a complex repair in which perioperative bleeding i a significant, important and fre ...

STTR Phase I Uncertainty Quantification (UQ) technical feasibility demonstration using advanced mathematical techniques and Biologically Inspired Computing Architecture (BICA) concepts is proposed for Phase II prototype development. UQ in complex System of Systems (SoS) M & S environments is emphasized in Phase II. Graph theory based M & S techniques are explored that enhance and facilitate topi ...

DESCRIPTION provided by applicant The goal of this STTR Phase II collaboration between Purdue University and bioVidria Inc is to commercialize disruptive new technology for protein chromatography and then maximize its impact by serving the fastest growing segment of the pharmaceutical industry protein drugs The product is a reversed phase chromatography column that uses silica particles of ...

DESCRIPTION (provided by applicant): About 3-4% of all fractures are estimated to be open fractures, where the fracture is exposed through defects in the skin and soft tissues. This equates to about 250,000 open fractures in the United States annually. Open fractures present a high risk of infection. Infection results in considerable financial burden to both the patient an healthcare system, requ ...