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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. AAV2-ASPA-Based Metabolic Intervention for Alzheimer's Disease

    SBC: ASKLEPIOS BIOPHARMACEUTICAL, INC.            Topic: NIA

    Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are primarily comprised of polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Unfortunately, these grafts continue to have high failure rates due to secondary complications associated with acute thromboses and incomplete, unregulated cellular prol ...

    STTR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Accurate Prostate Cancer Diagnosis for Active Surveillance Patients Using a Novel

    SBC: ProDevice Medical Supplies and Equipment LLC            Topic: NCI

    Project Abstract Active surveillance (AS) is becoming more accepted as a reasonable treatment option for men with low-risk prostate cancer (i.e. Gleason score 6, clinical stage T2a, PSA lt 10). Many AS protocols at major institutions call for a prostate saturation biopsy after initial diagnosis to confirm that the patient has no areas of higher-risk prostate cancer. For most patients who underwent ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A daily client check-in system for outpatient substance abuse treatment

    SBC: COG ANALYTICS, LLC            Topic: NIDA

    Abstract Alcohol and illicit drug use remain highly prevalent in the US, and epidemiological surveillance surveys estimate that over 20.6 million individuals (~ 8% of the US population) meet standard diagnostic thresholds for substance use disorders (SAMHSA, 2011). Outpatient substance abuse treatment is the predominate method of treatment in the US for SUDs, typically involving intermittent cont ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Adaptive Management and Mitigation of Uncertainty in Fusion (AMMUF)

    SBC: Charles River Analytics, Inc.            Topic: MDA13T001

    Missile defense takes place in an uncertain and dynamic environment, so multi-sensor fusion must be employed to aggregate and merge disparate data from the battlefield. However, the fusion process is hindered by the vast amount of uncertainty in operational contexts, such as imprecise measurements and varying environmental conditions. Various algorithms and fusion processes have been developed to ...

    STTR Phase I 2014 Department of DefenseMissile Defense Agency
  6. Adduct Dipstick for Diagnosis of Acetaminophen Toxicity

    SBC: Acetaminophen Toxicity Diagnostics, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever in the world today. In large doses, APAP causes acute liver failure and is the leading cause of acute liver failure in the US. Thecurrent laboratory test for the diagnosis of APAP toxicity, measurement of APAP levels in peripheral blood, is only effective in the first 24 ho ...

    STTR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  7. A Device To Quantify Sweat Of Single Sweat Glands To Diagnose Neuropathy

    SBC: Neuro Devices, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Neuro Devices, Inc. will construct a dynamic sweat test (DST) for early detection of peripheral neuropathy. Neuropathy is detected by measuring the rate and volume of sweat secreted by single sweat glands (SGs) under the control of sudomotor nerves. The test has a major advantage over other tests of nerve function because SGs are accessible for analysis on ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  8. A Doppler Simulator for Vascular Ultrasound Training

    SBC: Sheehan Medical LLC            Topic: NIBIB

    We will develop and test a simulator of diagnostic vascular ultrasound for use in medical education and professional certification. The simulator will include not only two-dimensional (2D) images but also Doppler spectral waveforms to simulate duplex ultrasound scanning. The rationale is that education in diagnostic ultrasound has traditionally been based on an extended duration of clinical exposu ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Advanced Assessment to Accelerate Diagnostic Skill Acquisition

    SBC: Parallel Consulting, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Current approaches to medical education produce new physicians with insufficient clinical competency to practice effectively with limited supervision, which has serious implications for patient outcomes during hospitaloff hours. Up to 70% of patients admitted to a hospital are admitted on nights or weekends, when staffing is low and residents may be in charge o ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Advanced Bicycle Helmet Technology for Prevention of Traumatic Brain Injury

    SBC: APEX BIOMEDICAL COMPANY, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Traumatic brain injury (TBI) is an acquired neurological disorder that can cause long-lasting disability with limited treatment options. Therefore preventative strategies must be emphasized in high-risk activities to reduce the individual and societal burden of this pervasive injury. Bicycle activities account for 20 percent of all sports-related TBI, with ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
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