Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of a-L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias, cardiopulmonary obstruction, progressive neurologic impairment and death by age 15. MPS I is currently treated b ...

DESCRIPTION (provided by applicant): A binary probe-based DNAzyme cascade for rapid detection of MRSA/MSSA Project Summary This STTR Phase I project will develop a proof-of-concept molecular test for rapid detection of Staphylococcus aureus (SA) and differentiation between methicillin-resistant SA (MRSA) and methicillin-susceptible SA (MSSA) in the absence of PCR amplification. Binary DNAzyme pro ...

DESCRIPTION (provided by applicant): ROS Technologies, Inc, is a medical diagnostics company developing a blood test to predict sudden death risk in patients with heart failure (HF). Heart failure affects more than five million Americans and increases therisk of sudden death. This application sets out to develop a simple, inexpensive blood test to help predict sudden death risk that may prevent un ...

Project Abstract Active surveillance (AS) is becoming more accepted as a reasonable treatment option for men with low-risk prostate cancer (i.e. Gleason score 6, clinical stage T2a, PSA lt 10). Many AS protocols at major institutions call for a prostate saturation biopsy after initial diagnosis to confirm that the patient has no areas of higher-risk prostate cancer. For most patients who underwent ...

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the leading cause of chronic disability in the United States. A clinical goal in the treatment and prevention of OA is to develo replacement cartilage using tissue engineering (TE) technologies.Although TE cartilage currently lacks the mechanical resilience of native cartilage, the mechanical properties of TE constructs can be enhanced b ...

Abstract Alcohol and illicit drug use remain highly prevalent in the US, and epidemiological surveillance surveys estimate that over 20.6 million individuals (~ 8% of the US population) meet standard diagnostic thresholds for substance use disorders (SAMHSA, 2011). Outpatient substance abuse treatment is the predominate method of treatment in the US for SUDs, typically involving intermittent cont ...

The proposed effort will further refine the adaptive model-based estimation and control guidance law developed during the Phase 1 effort to work in a two-tier algorithm with an agile, game-theoretic guidance law that is immune to the acceleration of the target. The two-tier approach is used to bring the intercept vehicle close to the target while conserving fuel but still obtains good minimal mis ...

Missile defense takes place in an uncertain and dynamic environment, so multi-sensor fusion must be employed to aggregate and merge disparate data from the battlefield. However, the fusion process is hindered by the vast amount of uncertainty in operational contexts, such as imprecise measurements and varying environmental conditions. Various algorithms and fusion processes have been developed to ...

We will develop and test a simulator of diagnostic vascular ultrasound for use in medical education and professional certification. The simulator will include not only two-dimensional (2D) images but also Doppler spectral waveforms to simulate duplex ultrasound scanning. The rationale is that education in diagnostic ultrasound has traditionally been based on an extended duration of clinical exposu ...