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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

Displaying 1 - 10 of 3736 results
  1. Quantitative Handwriting Assessment Tool for Healthy and Impaired Children

    SBC: NewVentureIQ, LLC            Topic: NICHD

    No technology currently exists for objective assessment of handwritingeven though overmillion individuals in the United States suffer from disorders that affect handwritingincludingmillion children with dyspraxia and overolder adults with Parkinsonandapos s diseaseThis lack of assessment technology creates a barrier to effective carebecause occupational therapists cannot easily distinguish motor d ...

    STTR Phase I 2018 Department of Health and Human Services
  2. Cathepsin B inhibitor Drug Development for Traumatic Brain Injury


    Project SummaryTraumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegenerationThe problem in the brain injury field is that there are no effective therapeutic agents for TBI or TBI related conditionsAdvancements in new drug targets are necessary for new opportunities to discover effective therapeutics based on the target mechanismWe have identified cathepsin B as an ...

    STTR Phase I 2018 Department of Health and Human Services
  3. Mobile Augmented Screening Tool to Increase Adolescent HIV Testing and Linkage to Care

    SBC: Digital Health Empowerment, Inc            Topic: NICHD

    ABSTRACTAdolescents face increased HIV riskinfrequent testinginconsistent linkage to careand a lack of prevention related knowledgeWe propose to address this by completing and evaluating the Mobile Augmented ScreeningMAStool to increase youth HIV testing via a tablet based intervention in clinical settingsand then use text messages to facilitate linkage to care for those who test positiveand deliv ...

    STTR Phase II 2018 Department of Health and Human Services
  4. SnapCap: a device to decontaminate central venous catheters (CVC) with 5 snaps

    SBC: Contech Medical, Inc.            Topic: NICHD

    Project Summary Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line associated bloodstream infectionsCLABSIan important healthcare associated infectionCLABSIs cost the US healthcare system approximately $billion annuallyPronovostNEJMAdditionallyCLABSIs can be life threateningespecially in the very young and critically illEven whe ...

    STTR Phase I 2018 Department of Health and Human Services
  5. A novel RF coil and incubator for reducing acoustic noise in neonatal MRI

    SBC: NeoView, Inc.            Topic: NICHD

    PROJECT SUMMARY In this Phase I Small Business Technology TransferSTTRprojecta team of researchers at Cincinnati Childrenandapos s Hospital Medical CenterCCHMCwill work with the engineering team at NeoViewIncto design and build novel body coil and incubator prototypes for aTesla Neonatal Intensive Care UnitNICUMRI systemThese components will play a central role in NeoViewandapos s neonatal MRI pro ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Optimizing Direct Delivery of Nucleic Acid Therapeutics

    SBC: FHC, INC.            Topic: 105

    Project Summary While nucleic acid therapeutics have shown promise in rodent and nonhuman primate models of CNS diseasesall double blind clinical trials to date have failedOne likely explanation for this failure is poor therapeutic distribution in targeted brain regionsFor examplepost mortem studies of patients with Parkinsonandapos s Disease receiving intraparenchymal injections of AAV NTN demons ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Development and Production of Standardized Reference Diets for Zebrafish Research

    SBC: Meridian Biotech, LLC            Topic: 101

    The over arching goal of this Phase I SBIR proposal is to begin to optimize and implement standard reference diets for the ZebrafishDanio rerioan animal model of critical importance to the understanding of human health and development of vertebrate organismsA key problem in the industry is that standardized diets or feed management strategies have not been developed for Danio rerioThese diets are ...

    STTR Phase I 2018 Department of Health and Human Services
  8. Enhanced Software Tools for Detecting Anatomical Differences in Image Data Sets

    SBC: Kitware, Inc.            Topic: 105

    Project SummaryMorphometric analysis is a primary algorithmic tool to discover disease and drug related effects on brain anatomyNeurological degeneration and disease manifest in subtle and varied changes in brain anatomy that can be non local in nature and effect amounts of white and gray matter as well as relative positioning and shapes of local brain anatomyState of the art morphometry methods f ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Validation of a salivary miRNA diagnostic test for autism spectrum disorder

    SBC: Quadrant Biosciences Inc.            Topic: 103

    Autism spectrum disorderASDis a continuum of neurodevelopmental characteristics that includes deficits in communication and social interactionas well as restrictiverepetitive interests and behaviorsASD is an increasing public health concernwith aboutinAmerican children diagnosed with ASD inafold increase in prevalence over the pastyearsThe effect of ASD on both society and the economy is a large b ...

    STTR Phase II 2018 Department of Health and Human Services
  10. Novel Tetrahedron Beam CT for Point-of-Care Imaging in Ear, Nose, and Throat

    SBC: TetraImaging LLC            Topic: NIBIB

    ABSTRACT Point of care imaging is highly desired in otolaryngologic clinics for the diagnosis of earnose and throatENTdiseases including cancersDue to limited image qualitycurrent cone beam CTCBCTproducts act not as a substitute but rather as a complement to diagnostic Multi slice CTMSCTin maxillofacial and ENT imagingThe emerging multi source x ray source technology suggests new designs of CT sys ...

    STTR Phase I 2018 Department of Health and Human Services

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