Award Data

Artificial intelligence-assisted detection and imaging technology can gather data on underwater, surface, and aerial threats to gain situational awareness over opposing forces, and aids in navigating dangerous marine and terrestrial environments. Successful and efficient use of intel is crucial for strategic information warfare, but many current technologies require active monitoring to identify t ...

This overall research program is oriented towards a deeper experimental and theoretical understanding of meteorological properties of the marine wave boundary layer (MWBL) and laser light propagation in the marine environment. The main objective is to develop a periscope imaging, electronic warfare, and High Energy Laser (HEL) beam propagation model over the marine aerosol boundary layer for the i ...

Project Summary/Abstract Stroke is the leading cause of serious long-term disability and accounts for 4.6 million disabled people in the United States. Stroke-related costs total over $46 billion in the United States each year.1 Of the nearly 800,000 Americans who have a stroke per year, 87% experience ischemic stroke1, of which 49%-86% are attributed to either large vessel occlusions (LVO) or med ...

The proposed phase-I STTR research is an interdisciplinary effort to develop more effective clinical management of Status Epilepticus (SE) in collaboration with one of the leading neurological institutes in the world, the Barrow Neurological Institute in Phoenix, Arizona. SE is a life-threatening neurological emergency that can occur without warning and is characterized by recurrent seizures witho ...

The current state-of-the-art radiation detection materials have different drawbacks limiting their applications in the next-generation mobile radiation detection system. NP Photonics proposes to develop a novel scintillating glass that can be used to make large form-factor scintillators for nuclear battlefield operations. The proposed scintillating glass has the advantages of low cost, short decay ...

PROJECT SUMMARY/ABSTRACT In response to National Institute on Aging's (NIA) strategic plan and PAS-19-317, we propose novel therapeuticsto treat Alzheimer disease and related dementias (ADRDs). We have developed novel combinations of three natural product compounds, which modulate complementary pathways in multiple types of CNS cells (i.e., neurons, microglia) associated with AD pathology. These c ...

Current treatments for asthma, while reducing exacerbations in a subset of patients by focusing on airway inflammation, do not eliminate them. Asthma exacerbations are a significant cause of morbidity and mortality in asthma as they can lead to airway injury, lung function decline and death. Exacerbations in more severe asthmatics are of particular concern, as health care costs and lost productivi ...

ABSTRACT Inflammatory bowel disease (IBD) is a debilitating disease (without curative therapies) that is critically influenced by dysregulated inflammatory pathways. This A0 R42 STTR application focuses on a highly novel humanized monoclonal antibody (mAb), ALT-100, to target and neutralize eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a damage-associated molecular pattern protein ...

Project Summary Down syndrome (DS) is caused by human chromosome 21 trisomy (hsa21) and is the most common genetic form of intellectual and cognitive disability, occurring in ~1 in 700 live births. DS patients also exhibit age-related progressive cognitive decline, neurodegeneration, and the development of Alzheimerandapos;s disease (AD)-like pathology by 40-50 years of age. There are currently no ...

Intelligent detection and imaging technology hold considerable value for Department of Defense to attain situational awareness and advantage over opposing forces, and for aid in navigating potentially dangerous marine and terrestrial environments. Technologies obtain intelligence on underwater threats and can gather intelligence on approaching surface threats. Current sensor technologies require a ...