Award Data

1 PROJECT SUMMARY2 Humans are living longer, resulting in our bodies outliving our brains. Although behavioral changes and better3 management of health conditions can help reverse or slow down premature decline in brain function, pre-4 symptomatic adults are not identified early enough when these changes would make the most significant positive5 impact. Effective intervention requires early detect ...

Project Summary As a participant in the new IDeA Regional Entrepreneurship Development (I-RED) program, the goal of this proposal is to create an educational product to promote entrepreneurism and commercialization in the Mountain West region of IDeA states. The educational product and overall program are intended to address the needs of IDeA state academic institutions in developing and strengthe ...

SummaryResting-state functional MRI (rsfMRI) is a rapidly developing task-free approach for presurgical mapping. It can complement task-based functional MRI (tfMRI) in patients who have difficulties performing tasks and efficiently map resting state networks (RSNs) in regions that are not typically mapped with tfMRI due to time constraints, such as frontal cortex. It has the potential to provide i ...

7. PROJECT SUMMARY Breast cancer is the most common cancer worldwide and the most common cancer diagnosed in American women. While there has been good progress regarding detection and treatment methods, breast cancer remains the primary cause of death from malignant tumors. Hence, there is a critical need for the development of novel predictive and prognostic factors. Risk assessments are currentl ...

Project Summary As a participant in the new IDeA Regional Entrepreneurship Development (I-RED) program, the goal of this proposal is to create an educational product to promote entrepreneurism and commercialization in the Mountain West region of IDeA states. The educational product and overall program are intended to address the needs of IDeA state academic institutions in developing and strengthe ...

There is a growing need to accurately characterize nuclear materials not only for nuclear safeguards and nonproliferation treaty verification but also for forensics and provenance. At present, nuclear material identification requires samples to be collected and sent to laboratories for analysis using large and expensive equipment, such as inductively coupled plasma mass spectrometers (ICP-MS) or s ...

There is a growing need to accurately characterize nuclear materials not only for nuclear safeguards and nonproliferation treaty verification but also for forensics and provenance. Presently, nuclear material identification requires samples to be collected and sent to laboratories for analysis using large and expensive equipment, such as inductively coupled plasma mass spectrometers (ICP-MS) or se ...

PROJECT SUMMARY Diabetes mellitus is a group of metabolic disorders characterized by high blood sugar, which is caused by deficiencies in insulin secretion and/or insulin action. Chronic diabetes can result in complications such as heart and peripheral vascular disease, kidney failure, limb amputation, and blindness and can even contribute to carcinogenesis. Diabetes represents a significant healt ...

Non-tuberculous mycobacterial lung disease (NTM-LD) caused by Mycobacterium avium complex is a serious chronic infection causing permanent lung damage, and is difficult to treat, typically requiring 12-24 months of treatment with rifampin, macrolide and ethambutol. We hypothesize that combined deuterated ambroxol and [acyl-13C]INH will allow both pharmacokinetic and pharmacodynamic enhancement of ...

Project Summary While nucleic acid therapeutics have shown promise in rodent and nonhuman primate models of CNS diseasesall double blind clinical trials to date have failedOne likely explanation for this failure is poor therapeutic distribution in targeted brain regionsFor examplepost mortem studies of patients with Parkinsonandapos s Disease receiving intraparenchymal injections of AAV NTN demons ...