Award Data

SUMMARYInflammation after ischemia and reperfusion injury secondary to hemorrhagic shock is responsible for significant mortality and morbidity in the United States. Available intravenous fluids administered at the incident scene to treat hypovolemic shock do not completely prevent ischemia and reperfusion injury. Re-initiation of blood flow causes activation of several inflammatory mediators, suc ...

Widespread azole resistance among Candida and Aspergillus spp. along with emerging echinocandin resistance in C. glabrata and C. auris raises the specter of untreatable multidrug resistant fungal infections, even as advances in medicine (cancer chemotherapy, organ transplant, premature infants, HIV/AIDS therapy) have increased the size of the vulnerable population. Our proposal aims to develop a n ...

Due to the physical complexity and intrinsic randomness in metal additive manufacturing (AM), the process control is intractable, the part quality is not repeatable, and the existing models fail to give consistent results to guide process design. To address this challenge, Global Engineering and Materials, Inc. (GEM) and its team members propose to develop a digital twin (DT) for AM process to ena ...

Designing and simulating large-diameter metalenses in the long-wave infrared (LWIR) range poses significant challenges due to the cost of computation resources involved. To address this challenge, we propose a scalable 3D FDTD inverse design approach that utilizes axial symmetry to enable the development of integrated meta-optics for LWIR. Our approach incorporates discrete axial symmetry and radi ...

Global Engineering and Materials, Inc. (GEM), along with its team member Professor Ming-Chen Hsu’s research group at Iowa State University (ISU), proposes the development of an innovative and effective octree-based adaptive meshing tool for efficient multi-physics simulations for aircraft design and analysis. The proposed tool is capable of autonomously generating a common mesh from Computer-Aid ...

The NAVY seeks microwave curing process modeling and technology demonstration for the cost-effective fabrication of continuous carbon fiber reinforced thermoset composites with reduced cure time and energy consumption. Despite the relatively extensive research work done for the microwave curing of polymer composites, the technology extension for the fabrication of continuous carbon fiber-reinforce ...

To meet the demands of the N23A-T028 “Broadband, High Power, Low Loss N-polar GaN Radio Frequency (RF) Switches” program, MaXentric team proposes the SWING (SWItches using a Nitrogen polar (N-polar) Gallium nitride (GaN) program. During Phase I, the team will characterize and model a N-polar GaN HEMT device, especially for switch applications up to 110GHz.  In addition, the team will investig ...

This proposal aims to develop a low-power multifunctional imager that can simultaneously capture both near-field and far-field images. The proposed system consists of three essential elements: a multi-functional metalens, a vision algorithm for 3D estimation, object counting and tracking, and a low-power camera sensor, enabling rapid analysis, interpretation, and transmission of the collected data ...

ABSTRACT / PROJECT SUMMARYAcute ischemic stroke is poised for a revolution. With the advent of mechanical thrombectomy in the last decade, the worst clots can be removed. While thrombectomy has improved outcomes, most treated patients still have severe deficits, in large part due to secondary injury caused by ischemia-reperfusion injury. To solve this problem, many neuroprotective drugs were trial ...

Opioid use disorder (OUD) is highly prevalent among individuals with diagnosed anxiety disorders with more than 60% of individuals with OUD reporting a lifetime anxiety disorder. Co-occurring anxiety is linked to earlier and more rapid progression into OUD, poorer treatment outcomes, and high probability of co-use of other substances, particularly benzodiazepines (BZDs). BZDs are currently the sta ...