Award Data

Project Summary/Abstract The Tiny Cargo Company offers a unique, orally administered medical countermeasure for treatment and prevention of the gastrointestinal (GI) side effects of cancer radiation therapy (RT). Our therapeutic is comprised of milk-derived extracellular vesicles (mEVs) loaded with a safe and highly effective radioprotective drug – a formulation that we call Milactatm. RT compli ...

PROJECT SUMMARY Circadian rhythms play a vital role in promoting maternal health and managing pregnancy outcomes, including gestational diabetes, preterm birth, and postpartum depression. However, interventions to mitigate circadian rhythms disruption during pregnancy are lacking, despite readily available non-pharmacological circadian interventions. The circadian timekeeping system is strengthene ...

Fibrosis is an aberrant wound healing process characterized by progressive accumulation of extracellular matrix that ultimately destroys organ function. Progressive fibrosis is inherent to chronic kidney disease (CKD), which often leads to end-stage renal disease. Although patients can be maintained by hemodialysis while awaiting transplantation, their’s and their care-giver’s quality of life ...

PROJECT SUMMARY Total joint arthroplasty (TJA) procedures are estimated to rise by over 300% by the year 2030. Periprosthetic joint infection (PJI) is the most significant complication following TJA with healthcare costs exceeding $1.6 billion annually. Treatment of PJI generally requires surgical intervention combined with a prolonged course of antibiotics costing $50,000 per patient. Despite thi ...

In manned aviation environments – both military and commercial – AI support is being developed and researched for ground-based planning and operational decision support. Using AI in real-time with crews poses additional questions and issues. This research will provide the means to understand the measures and requirements to architect potential AI-Agent solutions before implementation. This fea ...

PROJECT SUMMARY. In this Phase I STTR project, Light Switch Bio will collaborate with Virginia Commonwealth University and the University of Pennsylvania for the early-stage development of IR-Platin, a first-in-class photoactivated chemotherapy for treatment of head and neck squamous cell carcinoma (HNSCC), the sixth leading cancer worldwide. Most patients with HNSCC present with advanced disease ...

Sensor systems aboard aircrafts address unique problems and are siloed in their objectives. A data silo is a term used to describe a data system that is insulated from other data systems. While keeping information categorized may lead to easier organization, the costs often outweigh the benefits. In aviation systems, data silos often lead to miscommunication, cognitive overload, and waste. These d ...

ABSTRACT Conduct disorder (CD) remains one of the most common, impairing, and costliest psychiatric disorders among youth. Youth with CD often face lifelong adjustment, mental health, legal, social, occupational, and physical health problems. A subset of youth with CD display callous-unemotional (CU) traits. Youth with CD and CU traits are more likely to engage in chronic criminal behaviors and de ...

To address the challenge DTRA faces in identifying rare objects of interest to defeat improvised threat networks using multispectral imagery, small business ARiA and research institution Michigan Technological University (MTU) will develop and demonstrate the feasibility of the Generative Augmentation Process (GAP). The Phase I effort will (1) conduct a proof-of-concept study for GAP by developing ...

This STTR Phase I project proposes novel deep learning models for generating realistic multi-spectral remote sensing imagery, specifically in the infrared (IR) and near-infrared (NIR) bands. The proposed system enables synthesis of semantically realistic imagery and provides parametric control of synthesizing objects-of-interest, type of terrain and land cover, time or season, weather, cloud cover ...