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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. rAAV5-hCNGB3 Gene Therapy for Achromatopsia: Safety and Efficacy in a Dog Model

    SBC: APPLIED GENETIC TECHNOLOGIES CORPORATION            Topic: N

    DESCRIPTION provided by applicant Complete achromatopsia is an autosomal recessive inherited congenital disorder of retinal cone photoreceptors Patients with complete achromatopsia experience extreme light sensitivity and daytime blindness and best visual acuity under non bright light conditions is usually or worse and generally stable over time In addition to poor acuity hypersensit ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  2. High-specificity affinity reagents for N-glycosylation site mapping and glycomics

    SBC: GLYCOSENSORS AND DIAGNOSTICS, LLC            Topic: 300

    DESCRIPTION Glycans have several distinct properties that make them excellent targets for disease biomarkers Firstly the location of the glycans on the cell surface makes them the first point of contact of cellular interactions and thus crucial in the control of normal metabolic processes Cell surface molecules are also strategically exposed for surveillance by the immune system allowing for ...

    STTR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  3. A Device to Quantify Sweat of Single Sweat Glands to Diagnose Neuropathy

    SBC: Neuro Devices, Inc.            Topic: 107

    DESCRIPTION provided by applicant We devised a new generation highly sensitivity method to diagnosis peripheral neuropathy early when the probability for reversal is greatest Cancer chemotherapy and diabetes are the most common causes of neuropathy in the USA Both cause decreased sweating abnormal circulation peripheral numbness pain and weakness If diagnosed early both are potentially ...

    STTR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Development of OCT Imaging Adapter for Interstitial Tissue Imaging

    SBC: WEST FACE MEDICAL DEVICES, INC.            Topic: NIBIB

    DESCRIPTION provided by applicant This Phase I STTR Grant Proposal requests $ support for WestFace Medical Device to construct and test the WestFace Imaging Adaptor in conjunction with Ruikang K Wang PhD and his laboratory at the University of Washington Utilizing optical coherence tomography OCT the patented OCT Adaptor USPTO Pats provides r ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Intelligent Reasoning on the Impact of Changes to System Models and Requirements

    SBC: Discovery Machine, Inc.            Topic: MDA11T003

    As complex systems develop, there are inevitably changes to requirements and the system models as the team members formulate a more clear understanding of the customer needs and possible solutions. Often these changes are not coordinated since it is difficult to predict how one change may affect another and current requirements management and system modeling tools don't provide the type of t ...

    STTR Phase II 2013 Department of DefenseMissile Defense Agency
  6. AIMSMART: Adaptive, Interactive MDA Semantic Model-based Articulation

    SBC: CYCORP, INC.            Topic: MDA11T003

    We will develop automatic ontology-aligning software, leveraging the enormous existing Cyc AI system to drive the formulation and ranking (pro/con argumentation) of hypotheses about term-term relationships, especially where the relationship is not simple 1-to-1 correspondence. Multiple Cyc micro-theories (contexts) will be created, to hold incommensurate alternative mappings, and logical conseque ...

    STTR Phase II 2013 Department of DefenseMissile Defense Agency
  7. RF-IR Data Fusion

    SBC: DECIBEL RESEARCH, INC            Topic: MDA12T002

    The development and integration of three unique and innovative algorithm prototypes into a"Fused Track and Characterization Schema"are proposed. This Schema will encompass the determination of signatures and characteristics of objects that can be identified by RF and EO/IR Sensors in order to enable multi-sensor data fusion and correlation. The first algorithm, the"3D Pose Estimation"Algorithm, p ...

    STTR Phase I 2013 Department of DefenseMissile Defense Agency
  8. HEL Analysis Tool with Experimentally Corroborated DPAL Rate Coefficients

    SBC: CREARE LLC            Topic: MDA12T008

    Diode-Pumped Alkali Laser Systems (DPALS) have great potential for missile defense and other applications. Proper design of these systems is challenging because many interrelated processes impact their performance and critical kinetic rate coefficients are not well known. In response, our team proposes to develop a comprehensive physics-based analysis/design tool, and determine key kinetic rate ...

    STTR Phase I 2013 Department of DefenseMissile Defense Agency
  9. Verification and Validation of Physics Based DPAL Models

    SBC: AEROSOFT INC            Topic: MDA12T008

    AeroSoft, with the USAFA Laser and Optics Research Center proposes to create an extensive and thorough Verification and Validation (V & V) Program for anchoring physics based modeling software for static and flowing DPAL systems. During Phase I, a review of existing experimental programs will made and used for preliminary validation with the GASP software suite. Once deficiencies in the current e ...

    STTR Phase I 2013 Department of DefenseMissile Defense Agency
  10. Ultra-High Efficiency Multi-Physics CFD Simulation Software for DPAL/Laser System Analysis

    SBC: CU AEROSPACE L.L.C.            Topic: MDA12T008

    The primary objective of Phase I work performed by the team of CU Aerospace and the University of Illinois is to produce a powerful and easy to use, parallel, fluid-dynamic, chemical-kinetic, and optical simulation software package that will function on any modern computational platform (Unix, Linux, Windows, MacOS), be applicable to a wide range of laser systems and other technical problems of in ...

    STTR Phase I 2013 Department of DefenseMissile Defense Agency

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