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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES INC            Topic: N/A

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  2. Endoscopically-guided optical coherence tomography for early cancer screening

    SBC: PHYSICAL SCIENCES INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal addresses a need for an improved technology for early cancer detection and rapid screening. Recent advances in nanotechnology and high resolution imaging have led to the development of new investigative t ools capable of probing biological tissues at the cellular level. These tools can be used to localize abnormal neoplastic cells and expedite th ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  3. Enhanced Contrast Imaging for Screening of Early Pancreatic Cancer

    SBC: PHYSICAL SCIENCES INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal addresses a real need for an improved technology for early detection and rapid screening of ductal pancreatic cancer. Very recent advances in nanotechnology and high resolution optical coherence tomography (OCT) imaging have led to the development of new investigative tools capable of probing biological tissues at the cellular level. These tools ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  4. The Crystal Optimizer: Kinetic Control of Protein Crystallization

    SBC: RAINDANCE TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Protein crystallization remains a bottleneck in the goal to determine the protein's structure. A microfluidic device denoted the Crystal Optimizer (XOpt) has been developed to optimize the kinetic pathway for the nuclea tion and growth of protein crystals once the lead conditions have been identified by other screening methods. The device drives each of hundred ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  5. Fully Compensated Dynamic Shim System for In Vivo MRI and MRS

    SBC: RESONANCE RESEARCH INC            Topic: N/A

    DESCRIPTION (provided by applicant): Functional MRI, diffusion MRI and MR spectroscopy and spectroscopic imaging have great potential for the study and diagnosis of disease and injury, and guiding surgical therapy. All of these methods benefit greatly fro m the added sensitivity, resolution and contrast from high field strength magnets (3T and above). However, the advantages of higher magnetic fi ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  6. A low-cost point-of-care diagnostic test for simultaneous HIV-1 and STI

    SBC: Infoscitex Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): An important approach for HIV/AIDS prevention is to diagnose co-infections that significantly increase the transmission of HIV. In this proposal, we propose to develop a rapid point-of-care (POC) test that simultaneous ly diagnoses HIV-1 and two sexually transmitted infections (STI's). Syphilis and genital herpes are STI's that enhance HIV transmission; if dia ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  7. Discovery of Zika virus therapeutics using a replicon assay

    SBC: MICROBIOTIX, INC.            Topic: R

    ABSTRACT The Zika virusZIKVis the cause of an explosive pandemic of infections across South and Central Americathe Caribbeanand the southeastern region of the United StatesZIKV is a flavivirusa family of small positive strand RNA viruses that includes Dengue virusDENVWest Nile virusWNVYellow fever virusYFVand hepatitis C virusHCVZIKV is transmitted to humans by mosquitoes of the Aedes genusFor the ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Intravascular molecular-structural NIRF-IVUS imaging of coronary artery disease

    SBC: IntraVascular Imaging, Inc.            Topic: NHLBI

    The goal of this Phase I STTR project is to constructoptimizeand test a clinically viable intravascular near infrared fluorescence intravascular ultrasoundNIRF IVUSimaging catheter for simultaneous molecular and structural diagnosis of coronary artery diseaseCADCAD is a worldwide leading cause of death and disabilityincluding acute myocardial infarctioncongestive heart failureand sudden cardiac de ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Exploration of Low-Cost Long-Timescale Free Energy Perturbations on FPGAs

    SBC: Silicon Insite, Inc.            Topic: 400

    Drug discovery is challenging and expensiveespecially in the phase of lead optimization whichpredicts binding to a targetComputational approaches can add substantial valueComputingrelative binding free energiesRBFEbetween congeneric molecules using molecular dynamicsMDgreatly reduces the search space and considerably improves convergenceThe Silicon TherapeuticsSTXINSITE platform uses an RBFE proto ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Formation and Structural Property Relationships of a Tetracalcium Phosphate Bone Adhesive Biomaterial

    SBC: REVBIO, INC.            Topic: NIA

    Project Abstract Approximatelyof all fractures occur in the small bones of the wristshands and feetamounting to more thanmillion annuallyConsidering functional losses associated with the locations of these injuriesproper reduction and fixation is critical to ensure optimal rehabilitation and recoveryComplex injuries that include irreducible fractures or segmental bone loss require operative fixati ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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