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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Omniphobic cerebral shunt to eliminate clogging and dysfunction

    SBC: FreeFlow Medical Devices LLC            Topic: 106

    PROJECT SUMMARY Hydrocephalus causes long term neurological problems and patient suffering. Current treatments, most of which involve surgical diversion of cerebrospinal fluid (CSF) with shunt catheters, fail at an alarming rate. Approximately 98% of all shunts fail within 10 years, and this failure rate is the dominant contributor to the $2 billion-per-year cost that hydrocephalus incurs on our h ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Multi-Modality Image Data Fusion and Machine Learning Approaches for Personalized Diagnostics and Prognostics of MCI due to AD

    SBC: MS Technologies Corporation            Topic: R

    Alzheimer’s Disease (AD) is a devastating neurodegenerative disease. The greatest treatment potential lies in early stages before irreversible brain damage occurs. Early treatment requires early detection of the disease. Imaging holds great promise for capturing early signs of AD. This capability can be substantially strengthened by integrating neuroimages of different modalities that characteri ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Catheter Based Cardiovascular Device Retrieval System

    SBC: Onocor LLC            Topic: NHLBI

    Recent advances in technology have made possible the treatment of a growing number of structural cardiovascular diseases by catheter based procedures. Atrial septal defects (ASD), ventricular septal defects (VSD), aortic aneurysm, congenital defects and valve disease are all currently being treated with catheter based strategies. These procedures are complex and are prone to device misplacement, e ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Discrete 3-D Electronics for Mobile Radiation Detection Systems

    SBC: Radiation Detection Technologies, Inc.            Topic: DTRA18B002

    Phase II will utilize knowledge gained from phase I work to develop and execute a manufacturing process suitable for producing quantities of 3-D printed discrete circuits for radiation detection systems.  The goal is to support mobile radiation detection system requirements for high voltage, analog amplification, and MCA functionality to produce differential pulse height spectra in time sequence. ...

    STTR Phase II 2020 Department of DefenseDefense Threat Reduction Agency
  5. Prevention of arthritis-induced bone erosion by inhibiting osteoclast differentiation by the haloanilide, N-Methyl Dichloropropionaniline

    SBC: ExesaLibero Pharma            Topic: NIAMS

    We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic. Millions of adults live with chronic RA, which has similar features. Inflammatory arthritis often r ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a Novel MRI Contrast Agent for Early Detection of Alcoholic Steatohepatitis

    SBC: INLIGHTA BIOSCIENCES L.L.C.            Topic: 999

    Abstract Chronic liver disease (CLD) is a major cause of morbidity and mortality worldwide[1-4]. Hepatic fibrosis can develop in patients with any type of chronic liver disease (CLD), including alcoholic liver disease (ALD), hepatitis C, hepatitis B, nonalcoholic fatty liver disease (NAFLD) and autoimmune hepatitis. The major clinical consequences of cirrhosis are liver failure and hepatocellular ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  7. A Deep Learning Model to Improve Pathologist Interpretation of Donor Kidney Biopsies

    SBC: PlatformSTL (DBA for NewVentureIQ LLC)            Topic: 400

    ABSTRACT More people die every year from kidney disease than breast or prostate cancer. Kidney transplantation is life-saving, yet the donor organ shortage and high organ discard rate contributes to 13 deaths daily among patients awaiting transplant. The decision to use or discard a donor kidney relies heavily on microscopic quantitation of chronic damage by pathologists. The current standard of c ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Enhanced Software Tools for Detecting Anatomical Differences in Image Data Sets

    SBC: Ligo Analytics            Topic: 105

    Project Summary Morphometric analysis is a primary algorithmic tool to discover disease and drug related effects on brain anatomy. Neurological degeneration and disease manifest in subtle and varied changes in brain anatomy that can be non-local in nature and affect amounts of white and gray matter as well as relative positioning and shapes of local brain anatomy. State-of-the-art morphometry meth ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  9. EpiZode: Noninvasive Seizure Screening in Preclinical Models of Epilepsy

    SBC: SIGNAL SOLUTIONS, LLC            Topic: NINDS

    EpiZode: Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disorders. Animal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approaches. Animal epilepsy model use typically requires expensive and labor-intensive experimentation, with invasive EE ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  10. A Sparse-readout Quantitative PET scanner for breast cancer therapy optimization

    SBC: PET/X LLC            Topic: 102

    Our goal is to improve how breast cancer therapies are matched to individual breast-cancer patients with early- stage disease by providing a timely evaluation of therapy efficacy during the window of opportunity between diagnosis and surgical resection. In so doing, we aim to direct patients more quickly to effective therapies, improving outcomes, and reducing toxicities and healthcare costs from ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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