Award Data

ABSTRACT This Phase STTR Phase II proposal aims to engineer and scale-up a synthetic metabolic pathway in a microbial host to produce UDCA and related compounds. Additionally, the UDCA produced from the engineered synthetic metabolic pathway will be used to synthesize derivatives for testing in our Alzheimer’s Disease cell and animal models. The proposed work has high intellectual merit for the ...

PROJECT SUMMARY Although the ubiquity of metabolic problems in pulmonary hypertension (PH) has been known for more than a decade, a wealth of new details on the nature of this problem presents the opportunity for intervention. A combination of experimental work in cells and animals and early trials in humans, suggests that these metabolic problems are part of the causation for PH, and that inactiv ...

Large-scale military and civilian planning problems are (1) distributed – decision-making is spread across multiple organizations, including organizations that must employ information that they are unable or unwilling to share; (2) heterogeneous – the domains of optimization and local criteria for optimality differ – and (3) hierarchical – higher levels of authority solve abstract versions ...

A Gaussian-Pareto Overbounding (GPO) software toolset will be developed for the verification and validation (V&V) of safety-critical Unmanned Aerial Systems (UAS). In particular, this includes the V&V of sensors used to operate UAS, including navigation systems, the Air Data System (ADS), the Power Monitoring System (PMS), and Collision Avoidance Systems (CAS). The model-based techniques offered i ...

Abstract Increases in life expectancy together with demographic trends have fueled a rapid increase in America’s elderly population. As the number of older Americans has grown, so has the prevalence of aging-associated diseases, including Alzheimer’s Disease (AD) and other related dementias (ADRD). An estimated 5.4 Million Americans had AD in 2012, and that number is expected to double by 2030 ...

Approximately 4% of the population, and 7% of combat veterans have nightmare disorder. Chronic nightmares are found in approximately 18% of patients with insomnia, 15% with anxiety and depression, and 50-80% of patients with PTSD. Annually, eight (8) Million Americans and 20% of Airmen and Soldiers serving in wartime operations and US conflicts are diagnosed with Post Traumatic Stress Disorder (PT ...

The issues in the Afghan evacuation highlight the Air Force is lacking in its capability to collect, compile, and disseminate data reports in a timely manner. The Air Force can only move as fast as its ability to disseminate information and make informed

PROJECT SUMMARY This proposal responds to PAR-18-870 titled “BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR).” This project is a Fast Track STTR with a phase I and phase II. The small business, Applied Universal Dynamics Corp. (AUD) is collaborating with the University of Minnesota (U of MN). The activity patterns of t ...

Inkit’s Reach Enablement Platform (REP) will save the Air Force millions of dollars through the streamlined process for spare part sourcing and ordering. Inkit’s software product suite enables end-users (in this instance, maintainers and CE personnel) to place automated digital orders to a network of configurable 3rd-party vendors. Not only does it allow efficiency regarding end-user and vendo ...

ABSTRACT MarPam Pharma is developing a one-time treatment for durable remission of human immunodeficiency virus (HIV) for patients treated with antiretroviral therapy (ART). This treatment is an autologous HIV-specific chimeric antigen receptor (CAR; specifically, CD4-MBL-CAR) T cell therapy that employs the CXCR5 chemokine receptor as a homing device to direct anti-HIV killer T cells into “hidd ...