Award Data

PROJECT SUMMARY Although the ubiquity of metabolic problems in pulmonary hypertension (PH) has been known for more than a decade, a wealth of new details on the nature of this problem presents the opportunity for intervention. A combination of experimental work in cells and animals and early trials in humans, suggests that these metabolic problems are part of the causation for PH, and that inactiv ...

The overall goal of the STTR effort is to develop a compact, robust laser for cooling, re-pumping, state preparation and state detection of ytterbium-based trapped ion quantum computers.  Researchers and developers of trapped ion systems are often limited

The overall goal of this Air Force effort is to develop and deliver efficient, single-pass quantum optical waveguide sources generating entangled photon pairs for use in high-rate long-distance quantum computing or quantum communications networks. The new

A reoccurring challenge in photonic quantum information science is that many computational and memory platforms including trapped ions, defect centers, neutral atoms, and quantum dots have transitions at visible wavelengths whereas silicon photonic infras

PROJECT SUMMARY Outer ear infections (otitis externa or OE) affect an estimated 10% of people in their lifetime, with associated healthcare costs amounting to over $500 million annually. The pathology is mostly treatable in the general population with topical antibiotics regimes, and can be supplemented in severe cases with systemic counterparts. However, incorrect application or non-compliance wi ...

Assays for accurate diagnosis of early stages of infection with biothreat agents, on the day of infection or within a few days of infection, will find wide use in both civilian and military applications These diagnostic assays, which are anticipated to be highly specific and sensitive, will add to the repertoire of tools of hospitals and clinics that serve our armed forces personnel deployed on th ...

SPECIFIC AIMSAntibiotic resistance among common bacterial pathogens is a serious public health problem as it compromises our ability to treat infectious disease. The resistance problem is compounded by the relative lack of discovery of new antibiotics, especially those with novel mechanisms of action. New antibiotics are critically needed as resistance to recently developed antibiotics is growing. ...

Project Summary/Abstract Every year, approximately 1,200 severe mistreatments happen in radiation therapy. Radiation therapy lawsuits rank in the top third of all medical specialties with an average of $313,000 per claim settled or litigated. The current method for detecting treatment errors is by a weekly patient chart check, where each treatment record is manually reviewed on a weekly basis. Thi ...

Advanced approaches for genetic or epigenetic modification of embryonic stemEScellsincluding TALENZFNor CRISPR catalyzed genetic modifications or modulation of gene expression via small RNAssynthetic mRNAsor recombinant transcription factorshave revolutionized our ability to modify the cells from which novel mouse lines are producedIn contrastprocedures for utilizing these cells within the context ...

Despite significance advances in anti retroviral treatments HIV associated neurocognitive disorder HAND remains prevalent and can affect a broad range of everyday activities An effective brief cognitive screen that could be implemented in busy HIV clinics where clinicians have limited time to provide care for patients with complex medical psychiatric and cognitive conditions has the poten ...