Award Data

PROJECT SUMMARY Although the ubiquity of metabolic problems in pulmonary hypertension (PH) has been known for more than a decade, a wealth of new details on the nature of this problem presents the opportunity for intervention. A combination of experimental work in cells and animals and early trials in humans, suggests that these metabolic problems are part of the causation for PH, and that inactiv ...

PROJECT SUMMARY/ABSTRACT With the increased use of mobile health (mHealth) apps to improve health outcomes, protecting private health data is becoming increasingly important. These mHealth apps are offered by healthcare providers and used by patients for various reasons such as paying bills, scheduling appointments, sending messages to providers, accessing lab results, and viewing prescriptions an ...

Project Summary Pre-clinical and pre-field toxicology testing of new drugs and chemicals does not routinely include direct assessment of human developmental neurotoxicity (DNT). Current standards for DNT testing require use of animal models with limited throughput and significant differences from human central nervous system (CNS) development. As such, many chemical products have required post-app ...

Pediatric limb loss, although relatively infrequent compared to adults, results in substantial hardship for children and their families. The principal business interest? iFIT Prosthetics, LLC®? successfully developed and manufactured innovative, fully adjustable, transtibial and transfemoral prosthetic devices, and demonstrated their safety, comfort, and functionality in adults. Made of injection ...

We propose to develop transmitter (TX) and receiver (RX) components that will enable up to 40 Gb/s communication over a free-space communication link (FSCL) operating in the mid-wave infrared (MWIR). Such components when commercialized will enable lower latency than satellite links, greater security than radio-frequency (RF), longer range than mm-wave, and greater availability in haze and turbulen ...

Project Summary The goal of this project is to commercialize a wireless, wearable system to estimate the tension in superficial tendons throughout the limbs during dynamic movements. Tendon tension provides an estimate of muscle force, which is important information for understanding biomechanical behavior in all types of movement. Understanding muscle-tendon function inside the body is especially ...

Assays for accurate diagnosis of early stages of infection with biothreat agents, on the day of infection or within a few days of infection, will find wide use in both civilian and military applications These diagnostic assays, which are anticipated to be highly specific and sensitive, will add to the repertoire of tools of hospitals and clinics that serve our armed forces personnel deployed on th ...

Hypersonic vehicles operate at high-temperature, in a highly viscous flow field, for extended duration. Shock waves and boundary layers interact (SBLI) at the control surfaces of these vehicles and further increase viscous drag and aerothermal heating compared with the base vehicle. The SBLI also dramatically raises the achievable pressure ratio at the control surface if well controlled. Over long ...

Project Summary/Abstract Every year, approximately 1,200 severe mistreatments happen in radiation therapy. Radiation therapy lawsuits rank in the top third of all medical specialties with an average of $313,000 per claim settled or litigated. The current method for detecting treatment errors is by a weekly patient chart check, where each treatment record is manually reviewed on a weekly basis. Thi ...

The technical objectives of this proposal are: 1) demonstrate a single-element, 4.6 micron-emitting quantum-cascade-laser (QCL) with > 40 % continuous-wave (CW) wallplug efficiency (WPE) at room temperature; (2) perform a comprehensive simulation to achieve a design for a monolithic QCL operating in a single spatial mode to 10 W CW output power; 3) perform a thermal-management analysis for the des ...