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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Therapeutic inhibition of Fas-mediated retinal cell death and inflammation in dry AMD

    SBC: ONL Therapeutics, Inc.            Topic: NEI

    PROJECT SUMMARY / ABSTRACT Age-related macular degeneration (AMD) is the leading, and due to the aging baby boomers, a growing cause of irreversible vision loss in the United States, and is strongly associated with exposure to cigarette smoke (CS) and high fat diets (HFD). While effective treatment is available for neovascular AMD, the AREDS II antioxidant vitamins are the only proven treatment fo ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  2. InheRET: A SaaS solution to identify patients at increased risk for hereditary disease.

    SBC: INHERET, INC            Topic: NCI

    PROJECT SUMMARY This project is to expand the InheRET Inherited Risk Evaluation Tool to include recommendations for testing of patients at increased risk for hereditary disease, adding patient navigation features and customizable database entries for healthcare providers. This will include the development, integration and testing of InheRET 3.0 followed by pilot testing in 5 diverse clinics. InheR ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. An Automated Patient Chart Error Detection System for Radiation Therapy

    SBC: Infondrian LLC            Topic: 101

    Project Summary/Abstract Every year, approximately 1,200 severe mistreatments happen in radiation therapy. Radiation therapy lawsuits rank in the top third of all medical specialties with an average of $313,000 per claim settled or litigated. The current method for detecting treatment errors is by a weekly patient chart check, where each treatment record is manually reviewed on a weekly basis. Thi ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury

    SBC: Mitovation, Inc.            Topic: 101

    Neonatal hypoxia/ischemia is a known cause of cerebral damage resulting from inadequate blood flow and/or oxygen delivery to the infant brain before, during, or after birth. The occurrence among hospital deliveries is ~2-4 per 1000 full-term births with a drastic increase among premature newborns. The deficit in oxygen delivery to the brain results in extensive damage and severe disabilities. Rest ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. The Sustainable Heartland Accelerator Regional Partnership (SHARP) Hub

    SBC: BBC Entrepreneurial Training & Consulting, LLC            Topic: 500

    Project Summary/Abstract Despite the investment of billions of dollars in biomedical research each year from NIH, barriers remain in effectively translating basic science discoveries from academia to commercial products that benefit patients. These barriers include a funding gap between basic research and commercial developments, a lack of knowledge by innovators on how to bring products to market ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A nanoparticle delivery system for CRISPR/Cas9 based therapeutics

    SBC: ATGC Inc.            Topic: 100

    Abstract Applications of customizable nucleases such as CRISPRclustered regularly interspaced short palindromic repeatsCasCRISPR associated proteinhave enabled efficient and precise gene correction in vitroand hold promises for eventually achieving in vivo gene correction therapyHoweverto apply CRISPR Casin therapeutic settingsseveral major challenges remain to be addressedihomologous recombinatio ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A brief iPad based screening measure for HIV associated neurocognitive disorders

    SBC: Digital Artefacts LLC            Topic: 105

    Despite significance advances in anti retroviral treatments HIV associated neurocognitive disorder HAND remains prevalent and can affect a broad range of everyday activities An effective brief cognitive screen that could be implemented in busy HIV clinics where clinicians have limited time to provide care for patients with complex medical psychiatric and cognitive conditions has the poten ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Advanced Nitric Oxide Release Bactericidal Urinary Catheters

    SBC: BIOCREDE INC.            Topic: 300

    DESCRIPTION provided by applicant In Phase I Biocrede developed a completely new urinary tract silicone Foley catheter with a andgt month shelf life made from a proprietary polymeric formulation to effectively reduce catheter associated urinary tract infections CAUTI via nitric oxide NO release for andgt weeks Key features of the new technology include catheters continuously d ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board

    SBC: VIDATAK, LLC            Topic: 600

    DESCRIPTION provided by applicant Effective communication between patients and healthcare professionals is essential to achieve positive clinical outcomes Patients who are unable to communicate effectively e g patients with limited English proficiency LEP those who are hearing impaired aphasic or have oral tracheal intubation experience extreme frustration panic anxiety sleeplessne ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Diabetes Insulin Guidance System to Improve Glycemic Control of Diabetic Patients

    SBC: HYGIEIA RESEARCH, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): According to UnitedHealth14 by 2020 half of all Americans would have either diabetes or pre-diabetes with an annual cost of 500 billion - mainly attributed to diabetes related complications. Diabetes is a growing epidemic yet treatment goals are seldom achieved, and patients endure detrimental complications. In the US, 65% of all insulin takers (most of which ...

    STTR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
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