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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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2-HOBA for Treatment of Pulmonary Hypertension
SBC: MTI Biotech Incorporated Topic: NHLBIPROJECT SUMMARY Although the ubiquity of metabolic problems in pulmonary hypertension (PH) has been known for more than a decade, a wealth of new details on the nature of this problem presents the opportunity for intervention. A combination of experimental work in cells and animals and early trials in humans, suggests that these metabolic problems are part of the causation for PH, and that inactiv ...
STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Multispectral Sensor for Chemical Composition Analysis of Ultrafine Aerosols in Air Quality Assessment
SBC: SPECTREE INC. Topic: RProject SummaryWe propose developing and validating a novel platform technology that combines the collection and chemical analysis of ultrafine particles using an in-situ multispectral technique. The sample, collected directly onto the analysis substrate, is analyzed via excitation-emission matrix (EEM) spectroscopy. This approach will be validated against laboratory combustion-generated aerosols, ...
STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Laser-based real-time Temperature Measurements in Detonation Environments
SBC: EXMAT RESEARCH INC Topic: DTRA19B001To support DTRA’s agent-defeat efforts, we will refine a laser-based Optical Thermocouple (OTC) technology and build and deliver to DTRA a hardened OTC prototype. This OTC system will be capable of quantifying the localized temporal evolution of temperature inside a detonation environment. The OTC technology is based on two-color fluorescence thermometry to determine the temperature. After laser ...
STTR Phase II 2022 Department of DefenseDefense Threat Reduction Agency -
Enhancing the quality of CBT in community mental health through AI-generated fidelity feedback
SBC: LYSSN.IO, INC Topic: 104Each year, millions of Americans receive evidence-based psychotherapies (EBPs) such as cognitive behavioral therapy (CBT) for the treatment of mental and behavioral health problems. Yet, at present, there is no scalable method for evaluating the quality of psychotherapy services. In research settings, human-based behavioral coding methods are used, but these are time consuming, costly, and rarely ...
STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health -
CBTpro: Scaling up CBT for psychosis using simulated patients and spoken language technologies
SBC: LYSSN.IO, INC Topic: 104Psychosis resulting from schizophrenia spectrum disorders and major mood disorders is one of the most disabling health concerns worldwide. Evidence-based psychotherapeutic interventions are recommended as standard of care by national psychosis treatment guidelines but are rarely accessible. Cognitive Behavioral Therapy for psychosis (CBTp) is the most well-researched psychotherapy for psychotic di ...
STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health -
Development and Commercialization of a Sample Preparation System for Time Resolved Cryo-Electron Microscopy
SBC: HUMMINGBIRD PRECISION MACHINE CO. Topic: 400Cryo-electron microscopy (cryo-EM) is a powerful technique for imaging biological molecules in which samples are preserved in a frozen, hydrated state before imaging using an electron beam. The technique provides an alternative to X-ray crystallography for structural characterization of biological samples that are not crystallizable or do not crystallize in their native state. While cryo- EM sampl ...
STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health -
Phase II STTR development of an intranasal/oral Spirulina-based PfCSP malaria vaccine.
SBC: Lumen Bioscience, Inc. Topic: NIAIDABSTRACT Vaccination represents the single most effective and cost‐effective medical intervention devised to date, saving lives and reducing morbidity and disability for billions of humans. Despite the early success of the oral polio vaccine, most vaccines are delivered parenterally, and as such are associated with pain, non‐compliance, biohazardous medical waste and the need for trained medic ...
STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health -
PIXUL-FFPE:High throughput platform for chromatin and DNA sample preparation from formalin fixed paraffin embedded (FFPE) tissue samples- supplement application.
SBC: MATCHSTICK TECHNOLOGIES INC Topic: 172Formalin-fixed paraffin-embedded (FFPE) tissue archives represent the largest clinically annotated human specimen repository. The estimated millions of available FFPE tissue samples provide a vast resource for the discovery of disease epigenetic pathways, biomarkers and drug targets. And yet, these samples are highly underutilized because current methods for extracting molecular information from F ...
STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health -
A Sparse-readout Quantitative PET scanner for breast cancer therapy optimization
SBC: PET/X LLC Topic: 102Our goal is to improve how breast cancer therapies are matched to individual breast-cancer patients with early- stage disease by providing a timely evaluation of therapy efficacy during the window of opportunity between diagnosis and surgical resection. In so doing, we aim to direct patients more quickly to effective therapies, improving outcomes, and reducing toxicities and healthcare costs from ...
STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health -
Circulating Diagnostic Markers of Infectious Disease
SBC: PATHOVACS INCORPORATED Topic: CBD18A001Assays for accurate diagnosis of early stages of infection with biothreat agents, on the day of infection or within a few days of infection, will find wide use in both civilian and military applications These diagnostic assays, which are anticipated to be highly specific and sensitive, will add to the repertoire of tools of hospitals and clinics that serve our armed forces personnel deployed on th ...
STTR Phase II 2020 Department of DefenseOffice for Chemical and Biological Defense