Award Data

Current treatments for asthma, while reducing exacerbations in a subset of patients by focusing on airway inflammation, do not eliminate them. Asthma exacerbations are a significant cause of morbidity and mortality in asthma as they can lead to airway injury, lung function decline and death. Exacerbations in more severe asthmatics are of particular concern, as health care costs and lost productivi ...

TITLE: Critical angle reflection imaging (CARi) for label-free quantification of molecular interactions SUMMARYMeasuring molecular interactions of proteins are critical for understanding protein functions and cellular processes, for discovery and validating biomarkers, and for developing and screening drugs. In particular, membrane proteins play key roles in many cellular functions and are the lar ...

Develop an Optical Emulator of complex Electromagnetic Maneuverability (EM) systems with Nanophotonics structure.

Gaining a deeper experimental and theoretical understanding of maritime turbulence and laser light propagation in the marine boundary is required to optimize the performance of critical communication and defensive and offensive laser light engagements. Increased understanding of beam propagation through the turbulent flows of the marine layer will help the US Navy improve the performance of beam o ...

The purpose of this program is to develop and demonstrate “CerFoil”, a radically new lightweight ceramic/composite propeller for use in small-unmanned air systems (SUAS). In the Phase I program, Hydronalix and Oklahoma State University team proved the concept of a high-strength high modulus propeller and tested the same showing potential for increased duration. The Hydronalix/OSU team will con ...

ABSTRACT The development of radiation-induced lung injury (RILI) is a potentially fatal toxicity in cancer patients undergoing thoracic radiotherapy or in individuals exposed to ionizing radiation (IR) from a nuclear incident. The pathobiology of radiation pneumonitis and radiation-induced lung fibrosis (RILF) is complex but includes the deleterious effects of unchecked inflammation (reactive oxyg ...

Abstract Melanoma is the deadliest form of skin cancer, affecting an estimated 1.2 million Americans. The disease has a high propensity for dissemination, and metastatic melanoma has a dismal prognosis, with a median survival of only 5–8 months. Healthcare costs for melanoma in 2021 are projected to reach nearly $4 billion, with a rising incidence rate. Despite considerable efforts in recent yea ...

Develop an electromagnetic (EM) beam propagation prediction toolset that combines the metrological Marine Wave Boundary Layer (MWBL) atmospheric model, the short pulse multi-band metrological toolset, and visualization software/hardware and uses compact single-aperture Light i detection and ranging (LIDAR) technology for estimating beam performance in the MWBL.

Mortality rates in intensive care units (ICUs) are unacceptably high and are directly related to the duration of mechanical ventilation that is required to support patients with respiratory failure. For example, acute respiratory distress syndrome (ARDS) is a vexing acute inflammatory lung disease requiring mechanical ventilatory support as the result of severe hypoxemia and respiratory failure. T ...

PROJECT SUMMARY/ABSTRACTA cerebral aneurysm is an abnormal enlargement or pouch that forms from a weakened vessel segment in the brain. Often going unnoticed and untreated, an aneurysm can cause a sudden and catastrophic hemorrhage or stroke. Approximately 15 % of patients die from an aneurysm rupture even before receiving medical attention and 25 % of patients die despite medical treatment. Patie ...