Award Data

DESCRIPTION:(provided by applicant) The goal of this project is to develop a novel inhibitor of methane formation in ruminant animals. Currently, monensin, a relatively nonspecific antibiotic, is widely used in the livestock industry. Monensin increases agricultural productivity by decreasing methane and increasing propionate production; however, it also inhibits ...

Hormonally responsive cancers, such as prostate and breast, are a major cause of morbidity and mortality in the aging population in the United States. These cancers can be treated by sex steroid antagonists by these compounds are costly and mutational escape occurs. Recent innovative approaches have used hormonotoxins to specifically target the cancer cells. Several such approaches are already in ...

DESCRIPTION (provided by applicant): Bisphosphonates are currently used as bone-specific palliative treatments for metastatic bone disease in multiple myeloma and breast cancer patients. However, bisphosphonate use has no proven impact on primary tumor burden and overall survival and only moderately reduces skeletal complications. Bisphosphonate conjugates were synthesized using proprietary techn ...

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DESCRIPTION (provided by applicant): Otoreflectance (OR) is a new class of hearing test instruments utilizing acoustic signals presented and recorded in the ear canal. OR instruments address limitations in existing screening and diagnostic instruments in such areas as: (1) detecting otitis media, (2) predicting conductive hearing loss, (3) augmenting the newborn hearing screening protocol to test ...

DESCRIPTION (provided by applicant): Individuals with disabilities who require the use of wheelchairs for all of their independent mobility often experience problems with chronic seat discomfort in their wheelchairs. In spite of this prevalent problem, very little research has been done and few products have been specifically developed to mitigate chronic wheelchair seat discomfort. Chronic wheel ...

DESCRIPTION (provided by applicant): The long-term objective of the proposed work is the development of innovative detection technologies for biochips (a.k.a. DNA microarrays). It is envisioned that the proposed technologies will enable the application of biochips to biodefense, particularly when a rapid and reliable diagnostic screen is required in the field. The Specific Aims of the proposed wo ...

DESCRIPTION (provided by applicant): Recent reports indicate that adolescents are not following the Dietary Guidelines and are far from attaining the Healthy People 2010 nutrition goals. Most eat too much fat and sodium and inadequate amounts of fruits, vegetables, and calcium. They are snacking more, on less nutritional foods. In addition, there is an alarming increase in the prevalence of obesi ...

DESCRIPTION (provided by applicant): Bisphosphonates are currently used as bone-specific palliative treatments for the tumor-induced bone diseases observed in breast cancer and multiple myeloma patients. However, bisphosphonate use has no proven impact on primary tumor burden and overall survival and only moderately reduces skeletal complications. Bisphosphonate conjugates were synthesized using ...

DESCRIPTION (provided by applicant): Bisphosphonates (BP) are a class of anti-resorptive drugs that target metabolic bone diseases characterized by accelerated states of skeletal turnover, such as post-menopausal osteoporosis. BPs have a high affinity for hydroxyapatite in bone matrix where it is released and incorporated by the osteoclast during bone resorption. Once intracellular, the BP disrupt ...