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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Multispectral Sensor for Chemical Composition Analysis of Ultrafine Aerosols in Air Quality Assessment

    SBC: SPECTREE INC.            Topic: R

    Project SummaryWe propose developing and validating a novel platform technology that combines the collection and chemical analysis of ultrafine particles using an in-situ multispectral technique. The sample, collected directly onto the analysis substrate, is analyzed via excitation-emission matrix (EEM) spectroscopy. This approach will be validated against laboratory combustion-generated aerosols, ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Laser-based real-time Temperature Measurements in Detonation Environments

    SBC: EXMAT RESEARCH INC            Topic: DTRA19B001

    To support DTRA’s agent-defeat efforts, we will refine a laser-based Optical Thermocouple (OTC) technology and build and deliver to DTRA a hardened OTC prototype. This OTC system will be capable of quantifying the localized temporal evolution of temperature inside a detonation environment. The OTC technology is based on two-color fluorescence thermometry to determine the temperature. After laser ...

    STTR Phase II 2022 Department of DefenseDefense Threat Reduction Agency
  3. Enhancing the quality of CBT in community mental health through AI-generated fidelity feedback

    SBC: LYSSN.IO, INC            Topic: 104

    Each year, millions of Americans receive evidence-based psychotherapies (EBPs) such as cognitive behavioral therapy (CBT) for the treatment of mental and behavioral health problems. Yet, at present, there is no scalable method for evaluating the quality of psychotherapy services. In research settings, human-based behavioral coding methods are used, but these are time consuming, costly, and rarely ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  4. CBTpro: Scaling up CBT for psychosis using simulated patients and spoken language technologies

    SBC: LYSSN.IO, INC            Topic: 104

    Psychosis resulting from schizophrenia spectrum disorders and major mood disorders is one of the most disabling health concerns worldwide. Evidence-based psychotherapeutic interventions are recommended as standard of care by national psychosis treatment guidelines but are rarely accessible. Cognitive Behavioral Therapy for psychosis (CBTp) is the most well-researched psychotherapy for psychotic di ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Improved Identification of the function of Novel and Partially Occluded Laboratory Equipment

    SBC: NOVATEUR RESEARCH SOLUTIONS LLC            Topic: DTRA19B002

    This STTR Phase II project proposes development of a statistical relational learning framework for identification of the function of laboratory equipment from imagery. The proposed framework uses semantic reasoning to incorporate evidence from multiple classifiers and feature extractors, domain knowledge, and scene context for scene understanding and labeling. The Phase II effort will focus on dev ...

    STTR Phase II 2021 Department of DefenseDefense Threat Reduction Agency
  6. Development and Commercialization of a Sample Preparation System for Time Resolved Cryo-Electron Microscopy

    SBC: HUMMINGBIRD PRECISION MACHINE CO.            Topic: 400

    Cryo-electron microscopy (cryo-EM) is a powerful technique for imaging biological molecules in which samples are preserved in a frozen, hydrated state before imaging using an electron beam. The technique provides an alternative to X-ray crystallography for structural characterization of biological samples that are not crystallizable or do not crystallize in their native state. While cryo- EM sampl ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Phase II STTR development of an intranasal/oral Spirulina-based PfCSP malaria vaccine.

    SBC: Lumen Bioscience, Inc.            Topic: NIAID

    ABSTRACT Vaccination represents the single most effective and cost‐effective medical intervention devised to date, saving lives and reducing morbidity and disability for billions of humans. Despite the early success of the oral polio vaccine, most vaccines are delivered parenterally, and as such are associated with pain, non‐compliance, biohazardous medical waste and the need for trained medic ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Technology transfer of behavioral economic tasks for assessing alcohol reinforcer pathology: Development and feasibility of a commercially-available tool for clinical practice

    SBC: BEAM Diagnostics, Inc.            Topic: 270

    PROJECT SUMMARY Alcohol use disorder (AUD) contributes to excessive disability, morbidity, and mortality in the United States. As one of the nation’s leading causes of death, public health guidelines recommend consistent standardized alcohol screening. However, screening for alcohol misuse is underperformed, laborious, and is susceptible to demand characteristics and concerns about stigmatizing ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  9. PIXUL-FFPE:High throughput platform for chromatin and DNA sample preparation from formalin fixed paraffin embedded (FFPE) tissue samples- supplement application.

    SBC: MATCHSTICK TECHNOLOGIES INC            Topic: 172

    Formalin-fixed paraffin-embedded (FFPE) tissue archives represent the largest clinically annotated human specimen repository. The estimated millions of available FFPE tissue samples provide a vast resource for the discovery of disease epigenetic pathways, biomarkers and drug targets. And yet, these samples are highly underutilized because current methods for extracting molecular information from F ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  10. A Sparse-readout Quantitative PET scanner for breast cancer therapy optimization

    SBC: PET/X LLC            Topic: 102

    Our goal is to improve how breast cancer therapies are matched to individual breast-cancer patients with early- stage disease by providing a timely evaluation of therapy efficacy during the window of opportunity between diagnosis and surgical resection. In so doing, we aim to direct patients more quickly to effective therapies, improving outcomes, and reducing toxicities and healthcare costs from ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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