Award Data

DESCRIPTION (provided by applicant): The general goal of this proposal is to assemble directed mutant gene sets quickly, cheaply, easily, and reliably. Mutant gene sets can share sub-assemblies, yielding savings of time, cost, and effort not possible if designed and assembled all as single genes. The approach is to build upon experience gained in Phase I, to extend and generalize methods of DNA de ...

DESCRIPTION (provided by applicant): The principal aim of this project is to develop a resource library of very high-resolution computer models and imaging data sets of human skulls. This skull database project, which builds upon and is an extension of the Tooth Atlas project, will be the first phase of a complete, whole body, osteology library. As the imaging and computer technology advances, th ...

DESCRIPTION (provided by applicant): Inadequate sensitivity and specificity of currently-used imaging methods for cancer screening of the breast motivates the development of new modalities capable of adding diagnostic information. EMAI (electromagnetic acoustic imaging) is a novel imaging method which exploits tissue electrical conductivity and acoustic properties for the purposes of cancer detect ...

DESCRIPTION (provided by applicant): This Phase II Small Business Technology Transfer study between Materia, Inc. and the University of Kansas intends to build upon successes of our STTR Phase I (R41 GM076765) by scaling up selected products, optimizing processes for their manufacture, and expanding the array of functionalized oligomers for commercialization. This proposal is a collaborative effor ...

DESCRIPTION (provided by applicant): The goal of this project is to develop functional magnetic resonance imaging (fMRI) tools for assessing and treating human patients with a brain neoplasm or other focal pathology involving the visual or motor systems, especially cerebral cortex. Invasive treatment of the pathology can cause debilitating neurological side-effects involving partial or complete lo ...

DESCRIPTION (provided by applicant): Methods for the delivery of therapeutics, tracking dyes, genes and other substances into complex neural tissue, organotypic cultures and cell types are limited in their effectiveness. The biolistic process, based on acceleration of carrier particles to sufficient velocity, has recently been shown to be a relatively effectual delivery method for neuronal systems ...

DESCRIPTION (provided by applicant): This project represents the first-ever comprehensive investigation to research, develop and introduce innovative application of radio frequency identification (RFID) technology for automatic identification, tracking and status-monitoring of blood and blood products across the entire transfusion medicine supply chain, from the point of collection to the delivery ...

DESCRIPTION (provided by applicant): Candida species are opportunistic fungal pathogens that have become among the most common causes of nosocomial infections in the United States and worldwide. Disseminated infections caused by Candida spp. have increased 15-fold in incidence in the last 15 years, and Candida is now the third most common cause of bloodstream infections. Even with modern antifunga ...

DESCRIPTION (provided by applicant): Red Hill Studios and the University of California, San Francisco (UCSF) School of Nursing proposes to develop a computer-based videogame training program for patients with Parkinson's disease (PD). The program will feature a customizable Physical Gaming Regimen that will be based on an existing training program that has proven to be effective in improving gait ...

DESCRIPTION (provided by applicant): Throughout the World Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen. In areas with poor sanitary conditions C. trachomatis causes trachoma the most common cause of preventable blindness in the World. In symptomatic cases, unless therapy is implemented in a timely manner, long-term sequelae including, pelvic inflammatory disease ...