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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Rapid assay for RNA targeted drugs: Instrumentation Supplement

    SBC: NUBAD, LLC            Topic: 300

    DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Assessing the Bite Counter as a Tool for Food Intake Monitoring: Phase II

    SBC: BITE TECHNOLOGIES, LLC            Topic: 300

    DESCRIPTION provided by applicant Self monitoring has been described as the andquot cornerstone of the behavioral treatment of obesityandquot Consistent self monitoring of energy intake is associated with improved dietary adherence and weight loss and maintenance The problem is that individuals are notoriously bad at self monitoring their intake and suffer from an underreporting bias The s ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Reversal of Myocardial Infarction by Localized Stimulation

    SBC: Micro Vide, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Heart attacks i e myocardial infarction or MI occur in more than million patients annually Advances in pharmacological therapy have dramatically improved survival following the initial MI Consequently the number of patients with previous MI continues to increase and as a result put in jeopardy millions of patients for development of heart failure I ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. AlInN/GaN HFET over Free-Standing bulk GaN substrates

    SBC: Sensor Electronic Technology, Inc.            Topic: MDA09T001

    This proposed research for Phase II consideration involves the growth of AlInN/GaN heterostructure field effect transistors (HFET) on bulk GaN substrates. By combining a homoepitaxial substrate for the growth of the heterostructures with the lattice-matching ability of the AlInN alloy, it is expected that the defect density in the eventual HFETs can be reduced significantally, ultimately improvin ...

    STTR Phase II 2012 Department of DefenseMissile Defense Agency
  6. Hybrid CMOS/Nanodevice Integrated Circuits

    SBC: Sensor Electronic Technology, Inc.            Topic: AF07T025

    We propose to develop a novel hybrid circuit approach combining CMOS and two terminal crosspoint nanodevices with a novel interface consisting of an array of pins with nanometer scale tips. Our CMOL approach will allow the fabrication of ultra-dense integrated circuits (up to 10^12 active devices per cm2) for advanced computing (up to 10^20 operation per cm2 per second), information storage and se ...

    STTR Phase II 2009 Department of DefenseAir Force
  7. Optimal Design of Compact Fuel Cell Hybrid Power Systems

    SBC: INTERACTIVE DATA VISUALIZATION            Topic: A06T014

    This work will continue the use of numerical methods to determine optimal design parameters for a compact hybrid fuel cell power system driven by a statistically determined load profile. Detailed physics-based models will be used to represent the bahavior of the components in the hybrid system. The components considered in the hybrid system for Phase II will be a PEM fuel cell, Li-ion batteries an ...

    STTR Phase II 2007 Department of DefenseArmy
  8. Modeling Languages and Analysis Tools for Complex Distributed

    SBC: Fremont Associates, LLC            Topic: AF04T023

    The Architecture Analysis and Design Language (AADL) is an SAE standard language for describing the software and hardware architecture of performance-critical real-time systems. In addition, the AADL standard allows the definition of annexes, i.e., formal extensions to the standard language to enhance the design specifications of hardware or software components. We propose to leverage the AADL la ...

    STTR Phase II 2005 Department of DefenseAir Force
  9. New Rare-Earth-Doped Glasses for Planar Waveguide Lasers & Amplifiers

    SBC: KIGRE, INC.            Topic: MDA96T002

    This STTR Phase II project continues the development of a new glass (designated MM-i) for ion-exchange glass waveguides and amplifiers used in l.55 um optical communication systems. There is excellent commercial potential for these glass materials and the waveguide lasers (lossless splitters) and optical amplifiers that may be fabricated from them. To date, development efforts in the communication ...

    STTR Phase II 2005 Department of DefenseMissile Defense Agency
  10. New Broad Band Rare-Earth-Doped Glasses For Optical Fiber Communications

    SBC: KIGRE, INC.            Topic: BMDO01T001

    Kigre is developing new scalable high gain broad band rare earth doped laser oscillator/amplifier glass materials & diode pump architectures in support of high energy and high power laser applications. What's new, exciting and different about Kigre's laser glass materials and constructs is the ability to efficiently store and extract 1000-10,000x more laser power from ultra-short gain lengths and ...

    STTR Phase II 2004 Department of DefenseDefense Advanced Research Projects Agency

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