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DESCRIPTION (applicant's abstract): Our long-term goal is to advance techniques and instrumentation for rapid, automated analysis of nucleic acids during amplification. Our approach is to add fluorescent probes before amplification and analyze the results in real-time, completing the entire process in 10-20 min. No additional sample processing, membranes, arrays, or ...

DESCRIPTION (Applicant's abstract): Our long-term goal is to advance instrumentation and techniques for rapid, automated and sensitive variant analysis of nucleic acids. The LightCyclerTM has been our homogenous "closed system" platform for genotyping. Fluorescent hybridization probes are included at the beginning of the reaction and are used for realtime P ...

DESCRIPTION: The goal of this project is to develop a novel, non-invasive laser-optical technology for early diagnosis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly in the United States. The proposed development of a compact, low-cost diagnostic apparatus could ultimately provide the ophthalmologic and optometric c ...

The overall objective of the Phase II program is to develop a database of geopolymer-derived functional materials systems for ceramic matrix composities, including candidate materials for matrices and fiber-matrix interphase layers, which provide appropriate materials properties for performance in high temperature hydrothermal operating conditions at acceptable composite processing costs. Bot ...

The Architecture Analysis and Design Language (AADL) is an SAE standard language for describing the software and hardware architecture of performance-critical real-time systems. In addition, the AADL standard allows the definition of annexes, i.e., formal extensions to the standard language to enhance the design specifications of hardware or software components. We propose to leverage the AADL la ...

DESCRIPTION (provided by applicant): Our objective is to provide a homogeneous, closed-tube system for DNA mutation scanning on a high-throughput platform. For many complex genetic diseases, it is very difficult and expensive to screen for all possible mutations that may cause the disease. We propose a relatively simple solution. Certain dyes are compatible with PCR and can detect sequence alterat ...

DESCRIPTION (provided by applicant): Our objective is to provide a closed-tube system for rapid PCR, mutation scanning and genotyping that does not require fluorescently-labeled probes. For many genetic diseases, it is difficult and expensive to screen for all possible mutations that may cause the disease. We propose a relatively simple solution for rapid amplification, scanning and genotyping in ...

Scramjet propulsion has the potential to power high Mach number flight without the need to carry its own oxidizer like a rocket, thus significantly reducing vehicle flight weight. Numerical simulations will play an increasingly important role in the development of scramjet engines. Hydrocarbon fuels are advantageous for scramjet propulsion because of their higher energy density and ease of transpo ...