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The objective of this project is to develop multiscale simulation tools for coupled carrier-phonon transport in micro/optoelectronic devices and to explore novel concepts of phonon engineering for heat removal and termal management in advancedsemiconductor devices. The phase I effort resulted in a prototype software modules for multiscale simulation of phonon dynamics in LD semiconductors and prov ...

DESCRIPTION (applicant's abstract): Our long-term goal is to advance techniques and instrumentation for rapid, automated analysis of nucleic acids during amplification. Our approach is to add fluorescent probes before amplification and analyze the results in real-time, completing the entire process in 10-20 min. No additional sample processing, membranes, arrays, or ...

DESCRIPTION (Applicant's abstract): Our long-term goal is to advance instrumentation and techniques for rapid, automated and sensitive variant analysis of nucleic acids. The LightCyclerTM has been our homogenous "closed system" platform for genotyping. Fluorescent hybridization probes are included at the beginning of the reaction and are used for realtime P ...

DESCRIPTION: The goal of this project is to develop a novel, non-invasive laser-optical technology for early diagnosis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly in the United States. The proposed development of a compact, low-cost diagnostic apparatus could ultimately provide the ophthalmologic and optometric c ...

DESCRIPTION: (Adapted from Applicant's Abstract) A major limitation with the contemporary vaccination program as a preventative measure against tetanus is the encumbrance associated with multiple needle-dependent injections. Our aim is to develop a simple method for the delivery of tetanus vaccines by topical application of an adenovirus-vectored vaccine patch. The hyp ...

Anthracyclines such as doxorubicin and daunorubicin are valuable anti- cancer drugs but their clinical utility is compromised by cumulative dose-dependent by a cumulative dose dependent cardiotoxicity. Anthracycline cardiotoxicity has been linked to free radical damage via mechanisms that involve disruption of iron regulation and formation of superoxide anion. Although the quinone moiety of anthra ...

The overall objective of the Phase II program is to develop a database of geopolymer-derived functional materials systems for ceramic matrix composities, including candidate materials for matrices and fiber-matrix interphase layers, which provide appropriate materials properties for performance in high temperature hydrothermal operating conditions at acceptable composite processing costs. Bot ...

This proposal is for the design and development of a challenging, adaptable, and extendible AI system for use in state-of-the-art computer-based wargames. The development will result in a 3rd generation computer wargame based on modern air power conflict and the ability to apply the technology developed for this project in other wargames ranging from tactical ground-based warfare to naval conflic ...