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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Microbial Synthesis of Therapeutic Bile Acids for Alzheimer's Disease

    SBC: Metselex, Incorporated            Topic: 105

    ABSTRACT This Phase STTR Phase II proposal aims to engineer and scale-up a synthetic metabolic pathway in a microbial host to produce UDCA and related compounds. Additionally, the UDCA produced from the engineered synthetic metabolic pathway will be used to synthesize derivatives for testing in our Alzheimer’s Disease cell and animal models. The proposed work has high intellectual merit for the ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Programming Metabolically Fit TILs for Immunotherapy

    SBC: LIPO-IMMUNO TECH LLC            Topic: NCI

    ABSTRACT Advances in molecular biology and genetic engineering have led to the design and use of modified T cells recognize tumors to achieve significant tumor control upon adoptive cell transfer (ACT) to patients. These T cells are either transduced with tumor antigen reactive T cell receptors (TCR), or chimeric antigen receptors (CARs). Recently, a surge in studies with neo-antigen reactive T ce ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. HIDEHO: HIerarchical DistributEd Heterogenous Optimization

    SBC: SMART INFORMATION FLOW TECHNOLOGIES LLC            Topic: AF21BT001

    Large-scale military and civilian planning problems are (1) distributed – decision-making is spread across multiple organizations, including organizations that must employ information that they are unable or unwilling to share; (2) heterogeneous – the domains of optimization and local criteria for optimality differ – and (3) hierarchical – higher levels of authority solve abstract versions ...

    STTR Phase II 2023 Department of DefenseAir Force
  4. Zero Trust Methodology for Digital Modeling

    SBC: ISTARI, INC.            Topic: X22DOTCSO1

    At a high level, the major mission focus of this research is:  How can the DAF and broader DoD leverage Zero Trust methodology into digital model sharing and collaboration? The technical focus of this research is:  What is the best manner to link digital

    STTR Phase II 2023 Department of DefenseAir Force
  5. Gaussian-Pareto Overbounding for Verification and Validation of Safety-Critical eVTOL and UAM Operations

    SBC: ASTER LABS, INC.            Topic: AFX20DTCSO1

    A Gaussian-Pareto Overbounding (GPO) software toolset will be developed for the verification and validation (V&V) of safety-critical Unmanned Aerial Systems (UAS). In particular, this includes the V&V of sensors used to operate UAS, including navigation systems, the Air Data System (ADS), the Power Monitoring System (PMS), and Collision Avoidance Systems (CAS). The model-based techniques offered i ...

    STTR Phase II 2022 Department of DefenseAir Force
  6. Care Assistant for Family Caregivers of Persons with Dementia During Out of the Home Activities

    SBC: Koronis Biomedical Technologies Corp.            Topic: R

    Abstract Increases in life expectancy together with demographic trends have fueled a rapid increase in America’s elderly population. As the number of older Americans has grown, so has the prevalence of aging-associated diseases, including Alzheimer’s Disease (AD) and other related dementias (ADRD). An estimated 5.4 Million Americans had AD in 2012, and that number is expected to double by 2030 ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. 3D Printed Multifunctional Brain Windows for Simultaneous Optical Imaging and Electrophysiology

    SBC: Applied Universal Dynamics, Corp.            Topic: 102

    PROJECT SUMMARY This proposal responds to PAR-18-870 titled “BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR).” This project is a Fast Track STTR with a phase I and phase II. The small business, Applied Universal Dynamics Corp. (AUD) is collaborating with the University of Minnesota (U of MN). The activity patterns of t ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Affordable sialoglycans and associated reagents for expanded chemoenzymatic production

    SBC: Integrated Micro-Chromatography Systems, Inc.            Topic: 300

    Project Summary Sialoglycans are sialic acid-containing oligosaccharides that play important biological roles in human biology and pathology and are indispensable molecular probes for research related to bacterial and viral infection, cancer metastasis, immune regulation, etc. The multifaceted functions of sialoglycans in human milk are also being explored. Nevertheless, sialoglycan-related resear ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Cognitive Behavioral Therapy for Combat Related PTSD

    SBC: NIGHTWARE, INC            Topic: AF21BTCSO1

    Approximately 4% of the population, and 7% of combat veterans have nightmare disorder. Chronic nightmares are found in approximately 18% of patients with insomnia, 15% with anxiety and depression, and 50-80% of patients with PTSD. Annually, eight (8) Million Americans and 20% of Airmen and Soldiers serving in wartime operations and US conflicts are diagnosed with Post Traumatic Stress Disorder (PT ...

    STTR Phase II 2022 Department of DefenseAir Force
  10. Secure Document Generation

    SBC: Inkit Inc.            Topic: AF21BTCSO1

    The issues in the Afghan evacuation highlight the Air Force is lacking in its capability to collect, compile, and disseminate data reports in a timely manner. The Air Force can only move as fast as its ability to disseminate information and make informed

    STTR Phase II 2022 Department of DefenseAir Force
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