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DESCRIPTION: Accurate functional assessment of a user's abilities is a key component of successful computer access interventions. Continued development of an easy-to-use software tool is proposed for measuring users' skills in various kinds of computer interaction, including motor actions, perceptual activities, and cognitive activities. This tool will help practitioners ...

DESCRIPTION (Applicant's Description Verbatim): The hypothesis of this proposal is that a thrombin inhibitor that selectively interferes with platelet activation will be an important therapeutic agent in the management of acute coronary syndromes. Thromgen, Inc. is developing a class of agents called thrombostatin as antithrombin, anti-platelet drugs to be use ...

DESCRIPTION (provided by applicant): One in nine women suffer from pelvic floor dysfunction, including urinary incontinence and vaginal wall or uterine prolapse (VUP). Stress urinary incontinence (SUI) affects 38% of women over the age of 65 years and over 13 million women in the United States. Pelvic muscle strength is commonly assessed in these patients. However, current measurement techniques a ...

"FlesSys Inc. and the University of Michigan propose to develop and validate the performance of an active mechanical flow control device based on advanced complaint strictures technology. During STTR Phase I, PlexSys Inc (dba Mechnanical Compliance Inc.)has successfully developed a Gigh-Frequency Mechanical Vortex Generator by combining a compliant displacement-amplifier with a coice-coil generato ...

DESCRIPTION (provided by applicant): End-stage Lung Disease from all causes is the fourth leading cause of death in the US. Despite the success of lung transplantation, demand for donor lungs has steadily outgrown supply. Currently, the average wait is 2 years, with 30% wait-list mortality. Likewise, acute respiratory distress syndrome (ARDS) is a predominant cause of death in trauma and critic ...

Low-power Hall thrusters offer potentially important advantages for certain military applications but issues of lifetime and efficiency degradation at lower powers are issues hindering its utilization. A factor impacting efficiency is that the state-of-the-art techniques for electron generation used for neutralization (such as hollow cathodes operating on the same propellant as the thruster) do n ...

DESCRIPTION (provided by applicant): End-stage lung disease from COPD, cystic fibrosis, primary pulmonary hypertension, and ideopathic pulmonary fibrosis affects 15-17 million people in the United States and is the fourth leading cause of death in the U.S. With end-stage lung disease, carbon dioxide retention is a common and grave prognostic sign with limited treatment options. Long-term ventilato ...

DESCRIPTION (provided by applicant): The acute respiratory distress syndrome (ARDS) is a severe, life-threatening disease process that affects approximately 150,000 patients per year with an associated 30-40% mortality rate. Clinical studies are currently exploring the safety and effectiveness of Partial Liquid Ventilation (PLV), in which a perfluorocarbon-filled lung is gas-ventilated, in the ...

The Architecture Analysis and Design Language (AADL) is an SAE standard language for describing the software and hardware architecture of performance-critical real-time systems. In addition, the AADL standard allows the definition of annexes, i.e., formal extensions to the standard language to enhance the design specifications of hardware or software components. We propose to leverage the AADL la ...