Award Data

N/A

DESCRIPTION (Verbatim from the Applicant's Abstract): We propose to continue to develop and test a self-contained light delivery device for use in photodynamic therapy (PDT) for Barrett's esophagus. This device employs distally located semiconductor lasers at the end of a thin coaxial cable inserted into a balloon catheter. In Phase I, we successfully developed prototype un ...

DESCRIPTION (Scanned from the Applicant's Abstract): Selenium may play a significant role in cancer prevention. Dietary selenium aids in preventing several types of carcinomas including lung, prostate, and colon. The potency of Se varies with its chemical form. The most effective compounds are rapidly and quantitatively transformed by the body, such as Se-methylsel ...

DESCRIPTION (Applicant's abstract verbatim): Each year in the USA, more than 500,000 patients are hospitalized with venous thrombosis (VT) and pulmonary embolism (PE). Of these patients, nearly 200,000 die. Despite the magnificent advances in imaging techniques, diagnosis of VT and PE continues to be challenging. Because scintigraphic imaging technique is simp ...

DESCRIPTION (Provided by Applicant): Each year over 6,100 Americans undergo upper limb amputation requiring the use of prosthetic devices. With current devices, the patient is unable to mechanically and electrically control the prosthetic to mimic normal function. When nerves are severed or disrupted, the information for control is still present. A better, more natural control of the prosthesis co ...

Micromachined deformable mirrors are being commercialized by the contractor and applied to DOD related projects due to their light weight, fast response, small size, and inexpensive fabrication costs. During Phase II, the contractor and university teamwill demonstrate a novel projection system incorporating a micromachined deformable mirror, and develop a complete adaptive optics system based upo ...

DESCRIPTION (provided by applicant): Highly active antiretroviral therapy (HAART) has had a great impact upon reducing AIDS related morbidity and mortality. However, due to the high degree of HIV-1 variation, novel strains resistant to the present HAART cocktail of drugs have arisen. Coupled with the considerable toxicity associated with HAART, there is significant need for the discovery of new ...

DESCRIPTION (provided by applicant): Determining which amino acid residues of a protein form the binding site for a small molecule ligand, or that are present at the interface of a protein-protein complex, is difficult to identify from the crystal structure of the apo-protein. Recently, we have developed mass spectrometric methods coupled with heavy isotope labeling for mapping the location of ac ...

DESCRIPTION (provided by applicant): Current methods for assessing voice quality in patients with voice disorders that rely solely on either auditory perception, or acoustic analysis, are inherently inadequate. There is a pressing need to develop a reliable and objective measure of voice quality can be derived automatically from the acoustic signal, and at the same time is consistent with human pe ...

The main objective will be to optimize the benzoxazine resins and additives that were developed and tested during the Phase I program. The Phase II research will result in an increase in the oxidation resistant and strength and modulus so that these C/C composites will be suitable for many applications, especially as a replacement for titanium components in the 700 to 1200F temperature r ...