Award Data

DESCRIPTION: The specific objective of this STTR Phase II research and development project is to provide an optimized cellular therapy regimen for treating hypoxic-ischemic (HI) injury and its related outcomes in neonates. Pre- clinical studies performed in a rat pup model of HI injury as part of the funded Phase I STTR grant, point to benefit when Multipotent Adult Progenitor Cells (MAPC), a plur ...

DESCRIPTION (provided by applicant): The blood-brain barrier (BBB) is crucial for complex issues such as drug delivery, pathogenesis of chronic neurological diseases involving BBB dysfunction (e.g., brain tumors, ischemia, hypoxia, brain edema, multiple sclerosis, and meningitis) and issues related to bio-defense. Since the BBB selectively (by specific transport mechanisms) excludes most blood-bor ...

DESCRIPTION (provided by applicant): Over the past twenty-five years, there has been a sharp rise in the number of children and adolescents presenting to emergency departments (EDs) for psychiatric issues. Given that youth mental health issues account for 1.6% - 5.0% of all ED visits, and that Emergency Medicine physicians are the first to interact with these youth, the assessment of psychiatric i ...

Permanent magnet materials with high energy product of (BH)max = 30 MGOe at 450°C are needed for advanced Air Force power and weapon systems, which represents a 150% improvement in magnetic performance. Owing to the degree of difficulty this objective is unlikely achievable if using any existing permanent magnets, such as conventional high temperature SmCo5, Sm2Co17, or nanocomposite Sm2Co17/Fe- ...

The radical design proposed here essentially reinvents the venerable helical TWT. The cathode, electron gun, slow wave circuit, output coupler and collector would all be significantly different from current conventional practice. This is not innovation for the sake of novelty. Without radical changes, the physical limitations of the conventional helical TWT, which is the work horse of lower fre ...

The primary objective of this Phase-II research effort will be to complete the development of the electronic-resonance-enhanced coherent anti-Stokes Raman scattering (ERE-CARS) technique for quantitative in-situ concentration measurements of nitric oxide (NO) in high-pressure flames. The research effort will be focused 1) on investigating the pressure-scaling laws for NO ERE-CARS at pressures up t ...

MLPC and the University of Dayton will exploit a novel laser ablation technique, Through Thin Film Ablation (TTFA), to develop a controlled growth process for single wall nanotubes (SWNT). TTFA will allow formation of smaller catalyst particles and more precise control of the states of reactant species than conventional pulsed laser ablation techniques. Specialized plasma diagnostics will permit ...

DESCRIPTION (provided by applicant): Cholestasis (pathologic jaundice) is a very common sign of liver disease in children and adults, and results from genetic defects that play a critical role in bile formation and transport. In adults, mutations in the same genes also cause debilitating liver diseases or increased susceptibility to common biliary diseases, such as gallstones. Because many of the ...

The objective of this research is to improve the effectiveness of scalable wireless mesh networks in bulk data transfers and multimedia streaming. Several studies have shown that the performance of 802.11-based mesh networks degrades rapidly as the number of hops increases. Wireless mesh networks are vulnerable to security attacks. Current security approaches may be effective to a particular thr ...

UES, Inc., partnered with Princeton Plasma Physics Laboratory, proposes to develop a new method of controlling plasma parameters based on the nonlocal nature of the electron energy distribution function in plasmas. Specifically we propose to develop nonlocal plasma technology (NLP-technology) in plasmas with fast electrons - electrons with energies essentially greater than the average electron en ...