Award Data

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Military aircraft are largely constructed from special aluminum alloys, which typically have secondary precipitate phases that substantially improve mechanical strength. However, these regions also promote corrosion in such common environmental conditionsas acid rain, saltwater, and thermal cycling. The problem is significant enough that the U.S. Air Force expends approximately $1 billion per year ...

The Architecture Analysis and Design Language (AADL) is an SAE standard language for describing the software and hardware architecture of performance-critical real-time systems. In addition, the AADL standard allows the definition of annexes, i.e., formal extensions to the standard language to enhance the design specifications of hardware or software components. We propose to leverage the AADL la ...

DESCRIPTION (provided by applicant): The long-term goal of the collaboration between the USC and Southern Sun BioSystems is to create a plant breeding and remediation technology-development center which would supply hardware, protocols for breeding-selection and mass production of elite plants for nurseries and remediation businesses, with licensing and tracking mechanisms for protecting intellect ...

We propose to develop a novel hybrid circuit approach combining CMOS and two terminal crosspoint nanodevices with a novel interface consisting of an array of pins with nanometer scale tips. Our CMOL approach will allow the fabrication of ultra-dense integrated circuits (up to 10^12 active devices per cm2) for advanced computing (up to 10^20 operation per cm2 per second), information storage and se ...

DESCRIPTION (provided by applicant): The wound repair process in skin is initiated immediately after an injury and induces a cascade of events including inflammation, proliferation, and scar differentiation. The adverse changes in skin structure and function resulting from scar tissue affects over 35 million US citizens a year resulting in costs of more than 7 billion dollars). The founders of Fir ...

DESCRIPTION (provided by applicant): Anthrax is recognized as a class A bio-threat microbial pathogen that is readily weaponized and exceedingly difficult to treat. This bacterium is highly virulent inducing lethal infection in immunologically normal hosts by its intrinsic capacity to disseminate rapidly and induce sepsis, along with its ability to generate two highly potent exotoxins, lethal toxi ...

DESCRIPTION (provided by applicant): A major cause of morbidity and mortality in cardiovascular surgery is excessive bleeding post- operatively, which is commonly managed by pharmacologically modifying clot degradation (fibrinolysis), through inhibition of plasmin activity (PLact). However, the only FDA approved and most commonly used inhibitor of PLact in cardiovascular surgery, while effective i ...

DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...