Award Data

ABSTRACT Advances in molecular biology and genetic engineering have led to the design and use of modified T cells recognize tumors to achieve significant tumor control upon adoptive cell transfer (ACT) to patients. These T cells are either transduced with tumor antigen reactive T cell receptors (TCR), or chimeric antigen receptors (CARs). Recently, a surge in studies with neo-antigen reactive T ce ...

At a high level, the major mission focus of this research is:  How can the DAF and broader DoD leverage Zero Trust methodology into digital model sharing and collaboration? The technical focus of this research is:  What is the best manner to link digital

Project Summary Sialoglycans are sialic acid-containing oligosaccharides that play important biological roles in human biology and pathology and are indispensable molecular probes for research related to bacterial and viral infection, cancer metastasis, immune regulation, etc. The multifaceted functions of sialoglycans in human milk are also being explored. Nevertheless, sialoglycan-related resear ...

In May 2019, the Defense Health Board (DHB) released a report finding that the Military Health System (MHS) was endangering patient and warfighter lives by not adequately training for, measuring, and benchmarking the outcomes of low-volume, high-risk procedures. More than 30 years of healthcare research demonstrate that patient outcomes for procedures are significantly better in facilities that ro ...

Project Summary and Abstract Falls are the leading cause of death due to injury. Falls are so common that 30% of community dwelling older adults, and 50% of residents in Care Facilities will experience a fall in the coming year. The risk of falling substantially increases for those having Alzheimer’s disease and related dementias. The financial burden is significant with fall-related costs being ...

Project Summary/Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line-associated bloodstream infections (CLABSI), an important healthcare-associated infection. CLABSIs cost the US healthcare system approximately $2.3 billion annually (Pronovost, NEJM, 2009). Additionally, CLABSIs can be life threatening, especially in the very youn ...

PROJECT SUMMARYAminoglycosides are one of the cheapest and well-known antibiotics in clinical use for over 70 years, but one of the major limitations in their use is their ototoxicity. We are developing fast and low-cost methods to develop aminoglycosides with anti-ribosomal activities and reduced toxicity. In this project, we will identify novel aminoglycoside antibacterials, that show reduced ot ...

The overall goal of the STTR effort is to develop a compact, robust laser for cooling, re-pumping, state preparation and state detection of ytterbium-based trapped ion quantum computers.  Researchers and developers of trapped ion systems are often limited

The overall goal of this Air Force effort is to develop and deliver efficient, single-pass quantum optical waveguide sources generating entangled photon pairs for use in high-rate long-distance quantum computing or quantum communications networks. The new

A reoccurring challenge in photonic quantum information science is that many computational and memory platforms including trapped ions, defect centers, neutral atoms, and quantum dots have transitions at visible wavelengths whereas silicon photonic infras