Award Data

DESCRIPTION (provided by applicant): This STTR proposal to the National Institute on Aging (NIA) requests funding to expand the capabilities of the Medicare Research Information Center (MedRIC) recently established by Acumen, LLC with support from NIA. Thepurpose of MedRIC is to facilitate the acquisition and linking of data from the Centers for Medicare and Medicaid Services (CMS) to participants ...

DESCRIPTION (provided by applicant): Over the past two decades, the number of new antimicrobials being developed has experienced a greater than 60% decline, while the number of antibiotic resistant microorganisms has been steadily increasing. Only one newantibacterial drug with a novel mechanism of action (linezolid) has been introduced during this period making the long term outlook for sustained ...

DESCRIPTION (provided by applicant): The accurate quantification of skeletal muscle morphology is desired in a wide variety of medical areas such as muscle regeneration, muscular dystrophy, exercise physiology, and nutrition. For such studies, skeletal muscle is often fixed, sectioned, and labeled to visualize the borders of the muscle fibers, and digitally photographed. Investigators then use lab ...

DESCRIPTION (provided by applicant): Over 215,000 people will be diagnosed in 2008 with bronchial carcinoma in the U.S. according to the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. Currently, asthma afflicts22.9 million people in the U.S., and tracheomalacia is believed to afflict 3 million people in the U.S. In addition to these chronic or deadly c ...

DESCRIPTION (provided by applicant): NonAlcoholic Fatty liver is associated with obesity, and HCV infection, and is a leading cause of fibrosis, cirrhosis, and liver cancer. Lipid droplet formation (steatosis) is an underlying cause of the pathologies. However, there is considerable variation in the scoring of steatosis and fibrosis by pathologists. This proposal is for Phase II of the STTR projec ...

DESCRIPTION (provided by applicant): The use of tissue transfer flaps is a method of moving tissue from a donor location to recipient location and re-attaching the arteries and veins to the blood vessels at the recipient site. These procedures enable reconstructive surgery after trauma, as well as after surgical resection of cancer. Flap transfer surgery is subject to failure via a number of modes ...

ABSTRACT: Recent developments of advanced hybrid metallic structural concepts have been promising for enhancing durability and damage tolerance (D & DT) of unitized aircraft structures. The Alpha STAR team, comprised of Alcoa, Northrop Grumman (NGC), and Southwest Research Institute, proposes to demonstrate and verify/validate the application of advanced hybrid materials in a realistic large sca ...

ABSTRACT: Future Department of Defense space missions require precise, fine-positioning capabilities combined with large maneuvrability requirements. The purpose of this STTR is to: a) identify propellants for electrospray propulsion able to cover, at high propulsion efficiency, an unusually wide range of specific impulses, from several hundred seconds, typical today of colloidal propulsion up to ...

ABSTRACT: Carbon fiber-reinforced composites undergo subcritical damage well before final failure. A self-healing composite material is proposed that will autonomously sense and repair localized damage in composite structures. Healing is accomplished via two main components. The first component is a thermally remendable polymer matrix that is integrated into the structural carbon fiber composite ...

ABSTRACT: Predicting the wall heat loading experienced by hypersonic vehicles during the transition from laminar to turbulent boundary layer flow is the grand-challenge tackled by the present proposal. Previous studies have not focused completely on this phenomenon. In this work we adopt high-fidelity numerical simulations (Direct Numerical Simulation, DNS) to shed some light on the problem, with ...