Award Data

DESCRIPTION: (Adapted from Applicant's Abstract) A major limitation with the contemporary vaccination program as a preventative measure against tetanus is the encumbrance associated with multiple needle-dependent injections. Our aim is to develop a simple method for the delivery of tetanus vaccines by topical application of an adenovirus-vectored vaccine patch. The hyp ...

Anthracyclines such as doxorubicin and daunorubicin are valuable anti- cancer drugs but their clinical utility is compromised by cumulative dose-dependent by a cumulative dose dependent cardiotoxicity. Anthracycline cardiotoxicity has been linked to free radical damage via mechanisms that involve disruption of iron regulation and formation of superoxide anion. Although the quinone moiety of anthra ...

Our Phase II goal is to develop (model, design, fabricate and test) a miniaturized biofuel cell capable of generating energy from biomass to power the OFW sensor suite. Phase I goals were successfully met by demonstrating a prototype using glucose as fuel. In contrast to conventional technologies, this biobattery promises to be compact/lightweight, require little/no logistical support (re-supply ...

Terahertz plasma wave detectors and emitters utilizing the high-density 2-D electrons in submicron AlGaInN/GaN-based Quantum Well Heterostructure Field Effect Transistors (QW-HFETs)with high-sensitivity levels for the sensing of terahertz (THz) frequency electromagnetic radiation are proposed and developed.

Recent statistics from Operation Iraqi Freedom (OIF) show that significant proportion of soldiers injured in blast explosion endure traumatic brain injury (TBI). At the same time our understanding of TBI mechanisms and protection against kinetic and blast

Gel propulsion systems combine the best characteristics of solid and liquid propellants. The gel system stores like solid propellant, but flows like a liquid when pressurized, enabling throttle and restart capability similar to liquid propellants. An ena

DESCRIPTION (provided by applicant): The long-term goal of the collaboration between the USC and Southern Sun BioSystems is to create a plant breeding and remediation technology-development center which would supply hardware, protocols for breeding-selection and mass production of elite plants for nurseries and remediation businesses, with licensing and tracking mechanisms for protecting intellect ...

Mefloquine is known to cause adverse neurological effects, possibly attributable to single nucleotide polymorphisms (SNPs). Our objective is to develop a genetic screen capable of determining the susceptibility of an individual to Mefloquine neurotoxicity. In Phase I, transcriptional profiling of primary neurons exposed to Mefloquine was used to construct an intracellular pathway model to explain ...

Warfighters increasingly rely on radio communication equipment to ensure safety, mission effectiveness, and situational awareness. Current military communication gear involves headphones and acoustic microphones. Unfortunately, headphones cover the ears and deteriorate detection and localization of ambient sounds that may be important for tactical situations. An alternative to air conduction is bo ...

DESCRIPTION (provided by applicant): The overall goal of this Phase II project is to develop a novel R1-based method for MRI quantification of postinfarct myocardial viability using a commercially available contrast agent Gd(DTPA). The commercial embodiment of this method will be a software package that will convert a set of 2D cardiac MRI images to a 3D myocardial viability map, the Percent Infa ...