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Today, promising new protein targets for small molecule drugs are being discovered rapid. With increasing frequency, the 3D structures of these proteins are available or can be modeled from known protein structures. Demand is therefor growing for software to support structure-based discovery of protein ligands as candidate drugs. However, existing software leaves enormous room for improvement in a ...

DESCRIPTION (provided by applicant): Jet lag is a syndrome of behavioral, cognitive, and physical symptoms that result when travelers are exposed to a sudden shift of the day-night cycle. These symptoms impact on alertness and performance of airline and military personnel and the safety of the traveling public. They may also exacerbate medical and psychiatric illness, and frequent flyers may face ...

This project will develop a standard methodology that the U.S. military and others can use to evaluate the training efficacy of medical simulators. Both virtual and manikin simulators for training essential life-saving procedures, including IV insertionand airway intubation, will be assessed using this methodology during the Phase II period. A major objective of the Phase II project will be the va ...

In the phase I effort, IAI successfully demonstrated the feasibility of co-operative swarm based approach to boundary tracking. This approach is relevant to applications such as tracking oil spills using a swarm of robots, tracking enemy troop movement using a swarm of UAV's (Future Combat System (FCS) type scenario), and tracking of static and moving mine fields . In Phase II, we continue our ef ...

Development of an Optimal Bioaerosol Sampler with enhanced optical triggering capability is proposed, following a highly successful Phase I effort that clearly demonstrated feasibility. The threat of a bioaerosol attack can be partially mitigated by deployment of a cost-effective sensor network. High priority programs, such as BioWatch and Portal Shield will benefit from a sensor compliant to Join ...

Terahertz plasma wave detectors and emitters utilizing the high-density 2-D electrons in submicron AlGaInN/GaN-based Quantum Well Heterostructure Field Effect Transistors (QW-HFETs)with high-sensitivity levels for the sensing of terahertz (THz) frequency electromagnetic radiation are proposed and developed.

Techno-Sciences, Inc. (TSi), in collaboration with the Smart Structures Laboratory of the Alfred Gessow Rotorcraft Center at the University of Maryland (UMD), proposes to develop an innovative Active Pitch Link (APL) Technology for improved active rotor performance. The APL will exploit the superior performance characteristics of a new magnetostrictive material, GalFeNOL, and nano-particle enhance ...