Award Data

N/A

DESCRIPTION (provided by applicant): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (Aegis), a new, "rule based" molecular recognition system that carries protein ...

Terahertz plasma wave detectors and emitters utilizing the high-density 2-D electrons in submicron AlGaInN/GaN-based Quantum Well Heterostructure Field Effect Transistors (QW-HFETs)with high-sensitivity levels for the sensing of terahertz (THz) frequency electromagnetic radiation are proposed and developed.

DESCRIPTION (provided by applicant): The ultimate goal of our proposal is to genetically engineer a therapeutic human skin substitute for use in the treatment of skin lesions such as skin wounds (e.g., pathological or traumatic) and ulcers (e.g., venous and diabetic ulcers). Chronic skin ulcers are particularly problematic as they typically become infected resulting in impaired wound healing an ...

DESCRIPTION (provided by applicant): The principle of ALARA (as low as reasonably achievable) has been developed to reduce the risk of induced malignancy from radiation exposure, In practice this requires a rigorous quality control process for clinical operations in radiology. Currently, a critical tool (a radiographic test phantom) needed for quality control is not commercially available for c ...

DESCRIPTION (provided by applicant): Reading the conformational state of membrane proteins is central to understanding their role ir cell signaling, to using them as sensor elements and for screening candidate drug compounds that are targeted toward this important class of biomolecules. While the patch clamp technique for doing this is ubiquitous, it does have significant limitations: two electrod ...

DESCRIPTION (provided by applicant): The long-term goal of the collaboration between the USC and Southern Sun BioSystems is to create a plant breeding and remediation technology-development center which would supply hardware, protocols for breeding-selection and mass production of elite plants for nurseries and remediation businesses, with licensing and tracking mechanisms for protecting intellect ...

This work will continue the use of numerical methods to determine optimal design parameters for a compact hybrid fuel cell power system driven by a statistically determined load profile. Detailed physics-based models will be used to represent the bahavior of the components in the hybrid system. The components considered in the hybrid system for Phase II will be a PEM fuel cell, Li-ion batteries an ...

The high strength to weight and elasticity properties of spider silk make it of significant interest for the production of advanced fibers for military and civilian applications. Plants may offer the only feasible mechanism to produce quantities of spider silk proteins sufficient to sustain large scale manufacturing of these high performance fibers. Successful implementation of bioengineered spid ...

Hypergolic propellant gels offer improved safety and performance flexibility. However, their longer ignition delays endanger engine health and preclude widespread use. Understanding the physical and chemical paths to ignition can enable improving ignition and realizing favorable IM characteristics of gels. ORBITEC and JHU propose targeted laboratory and modeling experiments to elucidate phenome ...