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In Phase I we developed, integrated, and demonstrated a real-time adaptive navigation system, and a companion real-time adaptive guidance system for UAVs. The underlying project goal is to provide an aircraft with the capability to autonomously reroute itself in real time through dynamic hazard environments and still achieve its mission objectives. The adaptive naviagtion system uses an evolutiona ...

The transcription factor CAAT enhancer binding protein beta (C/EBPbeta) is a key factor orchestrating the inflammatory response. Specifically, expression of the genes encoding the pro-inflammatory cytokines IL-6 and on IL-8 are regulated by C/EBPbeta. C/EBPbeta can be either an activator or an inhibitor of inflammation depending on the dominant isoforms produced. Our data indicate that airway epit ...

DESCRIPTION (provided by applicant): Approximately 50,000 cancer patients a year have recurrent fluid accumulation in the space between their chest wall and lung. This condition is called malignant pleural effusion (MPE). This fluid impairs breathing and worsens the quality of life in these patients. The current treatments are not ideal and include removing the fluid by repetitive needle aspiratio ...

Kigre is developing new scalable high gain broad band rare earth doped laser oscillator/amplifier glass materials & diode pump architectures in support of high energy and high power laser applications. What's new, exciting and different about Kigre's laser glass materials and constructs is the ability to efficiently store and extract 1000-10,000x more laser power from ultra-short gain lengths and ...

DESCRIPTION (provided by applicant): Autoimmune diseases are difficult to diagnose, as the symptoms can be nonspecific. A single test that could readily distinguish between an autoimmune and non-autoimmune disorder would allow physicians to focus efforts on the specific disease that affects the patient. This is critical for diabetes mellitus (DM), which has two subsets, Type I and Type II. The sub ...

Massive blood loss is the most common cause of death in potentially survivable battlefield casualties, yet no definitive medical innovations have been made for reducing these deaths in the past several decades. It is still highly impractical to carry large volumes of refrigerated blood into battle, and substantial research for developing blood substitutes and extending the durability and portabili ...