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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Rapid assay for RNA targeted drugs: Instrumentation Supplement

    SBC: NUBAD, LLC            Topic: 300

    DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Assessing the Bite Counter as a Tool for Food Intake Monitoring: Phase II

    SBC: BITE TECHNOLOGIES, LLC            Topic: 300

    DESCRIPTION provided by applicant Self monitoring has been described as the andquot cornerstone of the behavioral treatment of obesityandquot Consistent self monitoring of energy intake is associated with improved dietary adherence and weight loss and maintenance The problem is that individuals are notoriously bad at self monitoring their intake and suffer from an underreporting bias The s ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Reversal of Myocardial Infarction by Localized Stimulation

    SBC: Micro Vide, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Heart attacks i e myocardial infarction or MI occur in more than million patients annually Advances in pharmacological therapy have dramatically improved survival following the initial MI Consequently the number of patients with previous MI continues to increase and as a result put in jeopardy millions of patients for development of heart failure I ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. AlInN/GaN HFET over Free-Standing bulk GaN substrates

    SBC: Sensor Electronic Technology, Inc.            Topic: MDA09T001

    This proposed research for Phase II consideration involves the growth of AlInN/GaN heterostructure field effect transistors (HFET) on bulk GaN substrates. By combining a homoepitaxial substrate for the growth of the heterostructures with the lattice-matching ability of the AlInN alloy, it is expected that the defect density in the eventual HFETs can be reduced significantally, ultimately improvin ...

    STTR Phase II 2012 Department of DefenseMissile Defense Agency
  6. New Rare-Earth-Doped Glasses for Planar Waveguide Lasers & Amplifiers

    SBC: KIGRE, INC.            Topic: MDA96T002

    This STTR Phase II project continues the development of a new glass (designated MM-i) for ion-exchange glass waveguides and amplifiers used in l.55 um optical communication systems. There is excellent commercial potential for these glass materials and the waveguide lasers (lossless splitters) and optical amplifiers that may be fabricated from them. To date, development efforts in the communication ...

    STTR Phase II 2005 Department of DefenseMissile Defense Agency
  7. New Rare-Earth-Doped Glass Fiber Lasers and Amplifiers for 1.54 um Communications

    SBC: KIGRE, INC.            Topic: N/A

    Kigre's Phase I fiber amplifier development effort demonstrated 10dB of internal gain at 1.54um from 2.2 cm long section of MM-2 erbium ytterbium phosphate fiber amplifier pumped at 980nm. 26dB of gain was also produced from a 8.8com long section of thissame fiber pumped at 1480nm. Mode field image testing of a fiber show this MM-2 fiber to be perfect 1.54um single mode containment match to stan ...

    STTR Phase II 2001 Department of DefenseMissile Defense Agency

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