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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Mechanical generation of peri-valvular oscillatory flow to prevent deep venous thrombosis.

    SBC: OsciFlex LLC            Topic: NHLBI

    Project SummaryDeep venous thrombosisDVTand secondary pulmonary embolismPEaffectof the population and cause approximatelydeaths annually in the USImmobility and lack of muscular activity is the primary risk factor for DVTan effect attributed to reduced venous flowAutopsy studies have identified the venous valve sinus in the leg as the site of origin for DVTbut a molecular and cellular mechanism fo ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a tracheal sound sensor for early detection of hypoventilation due to opioid overdose.

    SBC: RTM Vital Signs, LLC            Topic: R41

    Abstract More thanAmericans died from drug overdose inand drug overdose is now the most common cause of death for people underyears old in the United StatesFurthermorethe number of overdose deaths is increasing with the rise of abuse of powerful synthetic opioidssuch as fentanylIn May ofNational Institutes of HealthNIHand National Institute on Drug AbuseNIDAdirectors DrsCollins and Volkow outlined ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Discovering a Small Molecule that Targets the KSHV Processivity Factor for Treating Oral and Systemic Kaposi Sarcoma

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NIDCR

    Kaposi SarcomaKSis the most common cancer in themillion worldwide AIDS populationKS tumors are caused by Kaposi Sarcoma Associated Herpes VirusKSHVEven though HAART therapy has resulted in a dramatic decline in KS in the USthis malignancy remains the most predominant tumor of AIDSParadoxicallyKS tumors arise in some AIDS patients following HAART treatmentdue to Immune Reconstitution Inflammatory S ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Novel Bio-Adhesive Mesh System for Abdominal Hernia Repair

    SBC: CIRCA BIOSCIENCE, LLC            Topic: 300

    Development of a Novel Bio Adhesive Mesh System for Abdominal Hernia Repair Project Summary Abstract This project proposes the development of a novel mesh adhesive system for abdominal hernia repair utilizing surface modification of polymer surgical mesh to allow for improved tissue fixation with a poloxamine hydrogel adhesiveMore thanmillion Americans undergo hernia repair with surgical mesh each ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Preclinical Development of OCF001 for Treatment of Yeast Infections

    SBC: Sano Chemicals, Inc.            Topic: NIAID

    Project Summary OccidiofunginsA Dare cyclic nonribosomally synthesized antifungal peptides with submicromolar fungicidal activity against a broad spectrum of fungiOptimization of the production and isolation of occidiofungins from liquid cultures has been performedThe production and isolation of predominantly one analogcalled occidiofungin BOCFsupports its commercial development as a novel antifun ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Developing and validating a podocyte cell-based diagnostic assay for identifying recurrent focal and segmental glomerulosclerosis patients

    SBC: InDepth Pharmaceuticals, LLC            Topic: 400

    Diagnosing glomerular diseases accurately and in timely fashion is key to developing a successful treatment plan and thereby prevent their progression to ESRDend stage renal diseaseHowevertheir successful diagnosis remains challenging due to the complex diagnostic procedures used including invasive renal biopsiesThusthere is a compelling need to develop simplified procedures to detect glomerular d ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Serum Inflammasome proteins: Novel biomarker panel for radiation biodosimetry

    SBC: JT-Mesh Diagnostics LLC            Topic: NIEHS

    JT MeSh diagnostics is developing novel biodosimeter devices which will allow for rapidsimpleon site mass screening in the event of a nuclear disaster or an act of terrorismdirty bombBiodosimeters are critical in the event of a large scale radiological emergencyin the form of a nuclear disasterterrorist attack or radiation exposure of military personnelwhere a large population ofexposedindividuals ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a novel accurate therapy for Multiple Sclerosis

    SBC: Autoimmunity Biologic Solutions, Inc.            Topic: NIAID

    PROJECT SUMMARY Multiple SclerosisMSis the most common neurological disease of early adulthood and is mediated by autoimmune mechanisms that lead to demyelination and neuronal damage in the central nervous systemresulting in progressive neurological dysfunctionUp to datethere is no cure for the disease and current available treatments focus on preventing future immunological attacksprimarily by su ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Small-molecule combinationsexpand hematopoietic stem cell ex vivo and in vivo

    SBC: Advac Therapeutic LLC            Topic: NHLBI

    Small molecule combinations expand hematopoietic stem cell ex vivo and in vivo Abstract Hematopoietic stem cellsHSCsare featured by their self renewal potential and ability to differentiate into multiple blood lineagesHematopoietic stem cell transplantHSCTis a mainstay of life saving therapy for hematopoietic malignancies and hypoproliferative disordersThe use of noninvasively accessible umbilical ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Carbidopa, an iron chelator and an ABCG2 inducer, for treatment of gouty arthritis

    SBC: South Plains Biotechnology, Inc            Topic: NIAMS

    Our goal is to evaluate the efficacy of the FDA approved drug Carbidopa for the treatment of gouty arthritis in mouse modelsCarbidopa is used to treat Parkinson s diseasebut always in combination of L DOPAnever alone by itselfGouty arthritis is caused by deposition of monosodium urateMSUcrystals in jointsinitiating inflammation and arthritisInterestinglygout is not always directly related to incre ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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