Award Data

This Small Business Technology Transfer Phase I project will substantially advance 1) approaches to combine carbon nanotubes (CNT) into metal matrices, 2) processes to convert copper/CNT composites into wire while preserving CNT integrity, 3) methods to induce CNT alignment during either nanocomposite production or extrusion in order to optimize electrical conductivity, and 4) process control to e ...

This STTR Phase I project, Serious Game for Energy Science (SGES), proposes to address the question 'Can a serious game in Science, Technology, Engineering and Math (STEM), with artificial intelligence and teacher controls, engage the learner, impact student problem-solving abilities, increase interest in STEM-related activities/fields, and positively impact student learning outcomes in scien ...

This Small Business Technology Transfer Phase I project focuses on designing an eco-friendly, inexpensive cement hydrate with superior mechanical properties and applicable to several structural components. Cement is the key strengthening ingredient in concrete, the production of which accounts for ~2-3% of global energy use, and 5-10% of worldwide CO2 emissions. There is currently no other materia ...

This Small Business Technology Transfer Phase I project will develop a new Present Weather Sensor (PWS). The impact of this project will be felt in the transportation sector where, annually, 1.4 million traffic accidents are caused by weather at an estimated cost to the nation of $42 billion. Knowing whether freezing rain or snow is present greatly influences how Departments of Transportation appr ...

The broader impact/commercialization potential of this Small Business Technology Transfer (STTR) Phase I project is to produce an important platform chemical, hexanoic acid. Currently, the 6-carbon compounds are difficult to attain since crude petroleum contains just a small fraction in this carbon range as part of light naphtha. Most of the 6-carbon compounds are produced via multiple steps that ...

The broader impact/commercial impact of this Small Business Technology Transfer (STTR) Phase I project is development of a pulmonary function testing device for detection and diagnosis of pulmonary conditions. Today more than 650 million globally, nearly 10% of the world?s population, suffers from lung conditions like Asthma and Chronic Obstructive Pulmonary Disease (COPD). Currently, the most wel ...

DESCRIPTION (provided by applicant): The ultimate goal of this application is to develop a novel ex vivo purging method using myxoma virus (MYXV), a rabbit-specific poxvirus, to improve the clinical outcomes in treatment of multiple myeloma (MM). MM is aclonal plasma cell malignancy that has to date resisted essentially all therapeutic strategies. Currently, the standard of care for patients wit ...

DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a significant human health issue, accounting for 50% of liver transplants in the US, with approximately 170 million persons infected worldwide. The current standard of care therapy of PEGylated-interferon and ribavirin is effective in only about 50% of patients, with severe side effects and contraindications limiting patient ...

DESCRIPTION (provided by applicant): Recent studies of the applicants support the role of the endogenous gaseous biological mediator hydrogen sulfide (H2S) in colorectal cancer: selective upregulation of cystathionine-b-synthase (CBS) and the subsequent production of H2S in colonic cancer cells serves as a pro-survival factor by stimulating tumor cell bioenergetics, growth, proliferation, migratio ...