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PROJECT SUMMARY This project proposes to continue the development of AutoRegisterTMan integrated software based system for enhancing the accuracy of tumor change detectionThe intent of the system is to automate the alignment of a patient s brain scan with that of a prior scan such that subsequent offline tumor measurements do not have error introduced solely by differing slice orientationsWhile si ...

Polo like kinase PLK is a central player in regulating entry into and progression through mitosis Many studies have validated PLK as an anti tumor drug target and its inhibition is potently anti proliferative to cancer cells However recent data suggests that there are two major disadvantages of the conventional approach to blocking the kinase activity of PLK First both general kinome ...

Abstract Hepatocellular carcinoma HCC is a disease of growing incidence globally including in the US by per year With the recent success of anti viral therapies the etiology of HCC in the American population is projected to shift from viral HBV HCV hepatitis to primarily fatty liver disease in the near future Currently only one effective systemic therapy has been developed for HCC ...

Coronary artery disease remains the leading cause of death in the United States Platelets play an important role in the pathogenesis of acute coronary syndrome ACS as platelet activation aggregation and secretion are key components of arterial thrombus formation Despite dual anti platelet therapy for ACS and percutaneous coronary interventions PCI many patients sustain a high incidence u ...

Project Summary Abstract Radiation therapy is one of the primary therapeutic techniques for treating cancer Nearly two thirds of all cancer patients will receive radiation therapy during their illness with an average of radiation treatment episodes Although largely effective radiation therapy like other forms of cancer treatment has difficulty killing hypoxic regions within solid tumors ...

It is critical to have a validated modeling tool for fluid bed-based chemical looping combustion to develop scaled-up designs of equipment to reduce greenhouse gas emissions from coal and biomass fuels in power generation. The proposed work aims to develop such a modeling tool for widespread use in research and industry.

Neutron-sensitive microchannel Plates (MCPs) are now providing state-of-the-art user-based, high spatial resolution neutron imaging systems at several US government neutron research facilities as well as university research reactors. Using enriched 10B, thermalized neutron detection efficiencies exceeding 50% have been demonstrated, and cold neutron detection efficiencies of up to 70% have been do ...

Nickel super alloys, such as Inconel®, are leading candidates for fossil energy-based power production components due to their resilience in extreme environments. A significant technical roadblock to the implementation of nickel-based power plant systems is the inability to produce large-scale components in a cost competitive manner. We will address the problem of manufacturing large, low-cost su ...

PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

Age related macular degeneration AMD causes progressive loss of central vision and is the leading cause of blindness in the developed world A major challenge in the development of effective treatments for AMD is the lack of sensitive practical visual function endpoints People with AMD manifest delayed dark adaptation DA recovery and DA tests are a FDA approved method for diagnosing AMD Cu ...